Melanotan II (Melanotan 2) is a peptide that replicates the hormone responsible for stimulating melanogenesis in your body. When the alpha-melanocyte-stimulating hormone binds with melanocortin receptors, the outcome is the stimulation of melanin in skin cells.

Also, alpha-melanocyte-stimulating hormone exerts potent influence over sexual libido, appetite, and lipid metabolism. Melanotan II has actually been proven in studies to exhibit libido-enhancing, appetite suppressant, and lipolytic effects on top of promoting skin tanning.

Various studies have been conducted on Melanotan for its protective properties against harmful ultraviolet radiation effects from sun rays. This is due to its exceptional melanogenesis stimulating properties.

Additional studies comparing the similarities between Melanotan II and PT-141 show that both of these peptides can be used as a potent treatment for sexual dysfunction (sexual malfunction, especially male ED (erectile dysfunction).

The initial synthetic Melanotan 2 peptide was created by the UA (University of Arizona), a public research university. During a study aimed at developing a defence against skin cancer, the focus was put on developing a way of stimulating the natural melanin production in the skin, or natural melanogenesis, without direct exposure to ultraviolet radiation in sunlight, which are harmful.

UA researchers tried administering the occurring hormone, melanocyte-stimulating hormone, to elicit the desired result. Unfortunately, although the strategy showed promising outcomes, it discovered that this occurring melanocyte-stimulating hormone had a very short half-life considered of practical use as a curative remedy.

The positive results from melanocyte-stimulating hormone administration encouraged more research into the Melanotan 1 and Melanotan 2 development, exhibiting similar effects while having a half-life extended for practical therapeutic use.

Melanotan 1 and Melanotan 2 are analogues of the peptide hormone α-MSH (α-melanocyte-stimulating hormone) that induce skin tanning. Melanotan 2, unlike Melanotan 1, has proven to have aphrodisiac properties, which is the more positive effect of increasing sex drive (libido). MT 2 is a cyclic heptapeptide analogue of the α-MSH (α-melanocyte-stimulating hormone).

Also, Melanotan 2 underwent studies into the effects on food intake and diet of lab mice. Results showed that Melanotan 2 had activated the central melanocortin when induced and fed to the mice. Furthermore, the 6-day treatment of Melanotan 2 has revealed that the peptide reduced the adipose tissue and body weight in the mice’s viscera and suppressed the intake of calories.

Melanotan 2 helped in reducing serum insulin levels and the levels of cholesterol more than control treatments. Moreover, it suggested that Melanotan 2 lowers acetylcholine (ACh) A carboxylase expression. It also prevents palmitoyl transferase I mRNA and carnitine reduction in muscle-type tissues through pair-feeding in the obese rats’ muscles. Furthermore, Melanotan II peptides indeed increased fat catabolism in muscles and also improved cholesterol metabolism.

α-MSH (αlpha-Melanocyte-stimulating hormone) is an endogenous hormone that belongs to the melanocortin family. It is regarded as the most important MSH in melanogenesis stimulation, a process in mammals responsible for skin and hair pigmentation.

Furthermore, the αlpha-Melanocyte-stimulating hormone plays a role in energy homeostasis, feeding behaviour, and sexual activity (Melanotan 2 and Bremelanotide). The αlpha-Melanocyte-stimulating hormone is a nonselective agonist of the melanocortin receptors MC5, MC4, MC3, and MC1. Melanotan 2 and Melanotan 1 activate the MC1 receptor, responsible for the effects on skin pigmentation.

PT-141 (Bremelanotide) and Melanotan stimulate the MC4 and MC3 receptors, responsible for regulating sexual behaviour, metabolism and appetite. But, PT-141 Bremelanotide doesn’t stimulate the MC1 receptor.

Several synthetic analogues of the αlpha-melanocyte-stimulating hormone are studied for their photoprotective effects against UV (ultraviolet) radiation from sunlight.

Bremelanotide, another analogue of an αlpha-melanocyte-stimulating hormone-like Melanotan II, is being developed for sexual dysfunction treatment. All these Melanotan peptides have higher potencies than an αlpha-melanocyte-stimulating hormone but with unique selectivity peptide profiles.

Direct Peptides {name}, the leading supplier of Melanotan, is offering a wide variety of premium quality αlpha-melanocyte-stimulating hormone analogues tested at 99 per cent purity. We understand the significance of buying Melanotan peptides of the highest quality online to guarantee purity and greatest potency (stability) of your PT-141 and Melanotan when you shop online.

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