IGF-1 DES

Potential Benefits of IGF-1 DES Peptide

• Enhanced Cell Therapy for Acute Kidney Injury (AKI): A study synthesized a bioactive hydrogel by immobilizing the C domain peptide of IGF-1 (IGF-1C) on chitosan, hypothesizing that this hydrogel could provide a favorable niche for cell therapy in treating AKI [1].
• Cognitive Benefits: Research has explored the potential cognitive benefits of growth hormone/IGF-1 treatment, particularly in aged animals. The application of des-IGF-1 has been shown to alter the release probability for glutamate, which could have implications for cognitive function [2] and [3].
• Muscle Hypertrophy and Regeneration: Research has shown localized IGF-1 transgene expression has been found to sustain hypertrophy and regeneration in senescent skeletal muscle [4]. This could potentially be beneficial for countering sarcopenia, an age-related condition characterized by loss of muscle mass and function [5].
• Cardiac Health: According to research, cardiac-specific IGF-1 receptor transgenic expression has been shown to protect against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy [6].
• Potential Role in Alzheimer’s Disease Treatment: Research suggests that IGF-1 treatment could potentially be beneficial in Alzheimer’s disease (AD), although definitive assessments of the benefits and risks are still needed [7].
• Metabolic Regulation: Research studies indicate IGF-1, stimulated by growth hormone (GH), plays a role in regulating fat, protein, and glucose metabolism [8].

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4978042/

[2] https://pubmed.ncbi.nlm.nih.gov/15985695/

[3] https://www.sciencedirect.com/science/ article/abs/pii/S156816370500005X

[4] https://pubmed.ncbi.nlm.nih.gov/11175789/

[5] https://pubmed.ncbi.nlm.nih.gov/30953403/

[6] https://pubmed.ncbi.nlm.nih.gov/20215428/

[7] https://pubmed.ncbi.nlm.nih.gov/22503992/

[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6708115/