Leaders in Research Peptides

(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
Highest Quality | For Research Use Only

Humanin

Buy Humanin Peptide

Humanin is a small, mitochondria-derived peptide (MDP) consisting of 24 amino acids. It was first identified as a secreted factor from a cDNA library derived from the brain of a patient with Alzheimer’s disease (AD) and has since garnered considerable attention for its potential therapeutic properties.

Humanin exerts its effects through interactions with several receptors, most notably the formyl peptide receptor-like 1 (FPRL1) and BAX, a pro-apoptotic protein. Through these interactions, research has suggested Humanin can inhibit apoptosis, or programmed cell death, which is implicated in numerous diseases. Importantly, the anti-apoptotic activity of Humanin is highly specific to pathological or ‘bad’ apoptosis, making it an intriguing target for therapeutic intervention.

Showing all 3 results

Potential Benefits of Humanin Peptide

  • Mitochondrial Protection: According to studies, the Humanin peptide exhibits potent neuroprotective properties by acting on mitochondrial pathways. It inhibits Bax-dependent apoptosis, thereby safeguarding neuronal cells from oxidative stress and mitochondrial dysfunction [1].
  • Anti-Apoptotic Effect: Studies have shown that Humanin exerts an anti-apoptotic effect through the suppression of pro-apoptotic proteins like BAX and BID. It promotes cell survival and reduces cell death [2].
  • Counteracts Alzheimer’s Disease Progression: Humanin has been found to counteract Alzheimer’s disease pathology. Research suggests it interferes with amyloid-beta toxicity, one of the main culprits in the development of Alzheimer’s disease [3].
  • Promotes Metabolic Homeostasis: Research suggests that Humanin can regulate glucose metabolism and improve insulin sensitivity, thus contributing to metabolic homeostasis [4].
  • Anti-Aging Properties: Humanin levels decrease with age, and research suggests that supplementation with this peptide can combat age-related diseases and extend lifespan [5].
  • Cardiovascular Health: Preliminary studies indicate that Humanin may protect against cardiovascular diseases by reducing myocardial ischemia/reperfusion injury and attenuating atherosclerosis [6].
  • Role in Immunity: Studies indicate Humanin also plays a critical role in modulating the immune response, potentially offering protective effects against inflammatory and autoimmune disorders [7].

References

[1] https://pubmed.ncbi.nlm.nih.gov/14561895/

[2] https://pubmed.ncbi.nlm.nih.gov/12732850/

[3] https://pubmed.ncbi.nlm.nih.gov/11371646/

[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2709436/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4925829/

[6] https://pubmed.ncbi.nlm.nih.gov/23277413/

[7] https://pubmed.ncbi.nlm.nih.gov/19477263/

DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.