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Buy Melanotan II Peptide

Melanotan II (MT-II) is a synthetic analog of the pituitary-derived α-melanocyte-stimulating hormone (α-MSH) that has been designed to stimulate melanogenesis and increase melanin production. Research indicates this process aids in skin pigmentation, offering a protective layer against harmful ultraviolet radiation and potentially reducing the risk of skin cancer.

Research suggests MT-II has shown potential in other therapeutic areas, notably in the treatment of psychogenic erectile dysfunction. A double-blind, placebo-controlled crossover study found that MT-II initiated erections in men with this condition. However, the mechanism of action remains unclear and warrants further investigation.

Shop our Melanotan 2 Peptide Nasal Spray

What Is Melanotan II?

Melanotan II, also known as: MT2; Melanotan 2; or MT-II, is a synthetic peptide designed to stimulate the body’s melanogenesis, a process that leads to the production of melanin, the pigment responsible for the darkening of the skin. Initially developed as a potential preventive treatment for various skin cancers, it has gained popularity for its ability to induce tanning without the need for sun exposure.

Melanotan II works by mimicking the action of the naturally occurring hormone, alpha-melanocyte-stimulating hormone (α-MSH), to promote skin tanning, enhance sexual libido, and suppress appetite. Despite its popularity, it is important to note that Melanotan II has not been approved by health regulatory agencies in many countries due to concerns about potential side effects and long-term health impacts.

Melanotan II Mechanism Of Action

The mechanism of action for Melanotan II revolves around its ability to mimic the naturally occurring peptide hormone, alpha-melanocyte-stimulating hormone (α-MSH). This hormone plays a crucial role in regulating skin coloration by stimulating melanocytes in the skin to produce melanin.

When Melanotan II binds to melanocortin receptors (MC1R) on the surface of melanocytes, it triggers the melanogenesis process, leading to an increase in melanin production. This induced melanin production results in the darkening of the skin, simulating a tan.

Additionally, because α-MSH has effects on other melanocortin receptors that influence sexual arousal and appetite, Melanotan II can also inadvertently impact these functions, leading to its noted side effects of enhanced libido and reduced appetite.

Structure of Melanotan II

Melanotan II Structure
Source: PubChem

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2

Molecular Formula: C50H69N15O9

Molecular Weight: 1024.2 g/mol

What Are The Research Benefits of Melanotan II?

  • Enhanced Skin Pigmentation: Research suggests Melanotan II can increase skin pigmentation, potentially offering a viable method for sunless tanning. This melanocortin peptide stimulates melanogenesis by binding to melanocortin receptors in the skin cells [1].
  • Therapeutic Potential in Erectile Dysfunction: Clinical studies have demonstrated that Melanotan II can initiate erections in men with erectile dysfunction, indicating its potential therapeutic role in sexual health [2].
  • Libido Enhancement: Beyond its skin-darkening capabilities, Melanotan II has been observed to significantly boost sexual arousal and libido in users. This effect is attributed to its action on melanocortin receptors, which are not only involved in skin pigmentation but also play a role in sexual function.
  • Weight Loss and Appetite Suppression: There is emerging evidence in studies that Melanotan II may contribute to weight loss and appetite suppression, possibly due to its action on melanocortin receptors in the hypothalamus [3].
  • Potential Role in Heart Disease Prevention: Early studies suggest a possible preventive role of Melanotan II in heart disease, although further research is required for conclusive evidence [4].
  • Tissue Distribution and Metabolite Profiling: Advanced tools like spectrometry imaging have been employed to understand the tissue distribution, metabolic stability, and clearance of Melanotan II, providing valuable insights into its pharmacokinetics [5].
  • Tool for Physiological Studies: Melanotan II has been extensively used as a radio-labeled ligand in receptor studies, contributing significantly to our understanding of melanocortin receptor function and signaling [6].

What Are The Benefits Of Melanotan 2 Nasal Spray?

  • Non-Invasive Delivery Method: The Melanotan II nasal spray provides a non-invasive route for administration, enhancing ease and comfort for participants in research studies. This method significantly increases compliance and the practicality of repeated dosages, making it a preferred option for ongoing studies.
  • Rapid Absorption: The Melanotan II nasal spray offers swift absorption into the bloodstream through nasal delivery, bypassing the digestive system. This avoids first-pass metabolism, which can reduce the peptide’s effectiveness by breaking it down too soon.
  • Enhanced Bioavailability: Administering Melanotan II nasally increases its bioavailability, ensuring more of the active substance enters the bloodstream and potentially enhances research outcomes.
  • Suitable for Sensitive Peptides: Since some peptides are susceptible to breakdown in the gastrointestinal tract, the Melanotan II nasal spray offers a protective route of administration. This approach preserves the peptide’s integrity until it reaches its target site.
  • Ease of Use in Clinical Trials: For clinical trials necessitating patient self-administration, the Melanotan II nasal spray emerges as a straightforward alternative to professional administration or injections, enhancing participant adherence and overall trial feasibility.
  • Potential for Targeted Delivery: Exploring nasal delivery of Melanotan II offers potential for more effectively targeting the brain and central nervous system, thanks to the nasal passages’ close proximity to the brain.
  • Reduced Risk of Contamination and Infection: Compared to injectables, Melanotan II nasal spray reduces the risk of contamination and infection, particularly beneficial in extensive studies where repetitive injections present significant risks.

Frequently Asked Questions (FAQs) about Melanotan II

Q1: What is Melanotan II?

A1: Melanotan II is a synthetic peptide that mimics the action of a naturally occurring hormone, melanocortin, which influences skin pigmentation, sexual arousal, and appetite. It has gained attention for its potential effects on increasing melanin production, leading to a tanned appearance without exposure to UV radiation. The option to buy Melanotan II is for research purposes including studies in dermatology and cosmetic enhancement.

Q2: How is Melanotan II administered?

A2: Researchers studying Melanotan 2 can administer it via subcutaneous injections or nasal sprays, depending on the study’s design and participant tolerance. Nasal sprays are often preferred for their non-invasive nature and simplicity, improving participant compliance and the practicality of long-term studies. You can buy Melanotan II nasal sprays from Direct Peptides .

Q3: What are the potential benefits of using Melanotan II?

A3: The primary benefit associated with Melanotan II is its ability to stimulate melanin production, promoting a tanned skin appearance. Additionally, it has been reported to enhance sexual libido and reduce appetite, although these effects vary among individuals.

For those looking to buy Melanotan II, it is essential to consider the best source, ensuring product quality and effectiveness. Direct Peptides offers 99% purity peptides, buy Melanotan II from us today!

Q4: Are there any side effects associated with Melanotan II?

A4: Before you buy Melanotan II it is important to know about its side effects. Commonly reported side effects include nausea, facial flushing, increased libido, and appetite suppression. It’s crucial to consult with a healthcare provider before using Melanotan II to understand all potential risks and side effects.

Q5: How quickly does Melanotan II take effect?

A5: The time it takes to notice effects from Melanotan II can vary between individuals. Some may see changes in skin pigmentation within a few days of consistent use, while others might take a few weeks to notice substantial results. Consistency and proper dosage are key factors influencing the timeline of effects.

Q6: Is Melanotan II legal?

A6: The legal status to buy Melanotan II varies by country and region. In some places, it is available by prescription or for research purposes only. It’s important to check local regulations and ensure compliance with laws regarding the purchase and use of Melanotan II.

Q7: How should Melanotan II be stored?

A7: Unreconstituted Melanotan II should be stored in a cool, dry place away from light. Once reconstituted, the peptide generally needs to be kept refrigerated and used within a specific time frame to maintain its efficacy. Always refer to storage instructions provided with the product for optimal preservation.

Q8: How should Melanotan 2 nasal spray be stored?

Proper storage of Melanotan II nasal spray is key for its effectiveness and safety. Store it at room temperature, away from sunlight and heat to avoid active ingredient degradation. Do not freeze unless instructed. Ensure the cap is tight after each use to prevent contamination or air entry affecting the formulation. Always follow the product’s specific storage guidelines, as different formulas may have unique stability and effectiveness requirements.

Summary of Research Applications

  • Sunless Tanning Solution: Offers an alternative to traditional sunbathing and tanning beds, potentially reducing the risk of skin damage and skin cancer.
  • Erectile Dysfunction Treatment: Demonstrates therapeutic potential in improving erectile function, offering a novel approach to sexual health issues.
  • Libido Enhancement: Can significantly increase sexual desire, benefiting individuals experiencing low libido.
  • Weight Management: May aid in weight loss and appetite suppression, contributing to healthier lifestyle choices.
  • Heart Disease Prevention: Early research indicates a potential preventative effect against heart disease, adding to its diverse application spectrum.
  • Research Tool: Serves as a valuable tool in physiological and pharmacokinetic studies, enhancing our understanding of melanocortin receptor functions and signaling pathways.


Buy Melanotan II Nasal Spray online from Direct Peptides, a global supplier of premium grade peptides.

Buy Melanotan II : Melanotan 2 Nasal 15ml-Bottle

Melanotan II Peptide Quality Assured​

At Direct Peptides , we set a new benchmark for peptide solutions, providing Melanotan 2 peptides guaranteed to be 99% pure. Our rigorous attention to detail throughout the synthesis process guarantees that each batch not only meets but exceeds industry standards for quality and effectiveness.

Our commitment to premium purity not only reinforces our standing for outstanding quality but also enhances the therapeutic effectiveness of Melanotan II. This ensures our clients receive a product that consistently meets their research requirements with unmatched reliability.

By choosing to buy Melanotan II from us, you are investing in a product that exemplifies the highest standards of precision and purity in peptide research.

View our High-Performance Liquid Chromatography (HPLC) Certificate at this link.

References For Further Reading​

[1] Z.A.Malek et al (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides – Proceedings of National Academy of Sciences U S A. 1995 Feb 28; 92(5).

[2] H.Wessells et al (1998)  Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study – The Journal of Urology, . 1998 Aug;160(2):389-93.

[3] I.Côté et al (2017)  Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction – Canadian Journal of Physiology and Pharmacology,  2017 Feb; 95(2): 206–214.

[4] Gary D. Lopaschuk (2021) Targeting the Brain to Protect the Heart – JACC: Basic to Translational Science, Volume 6, Issue 1, January 2021, Pages 71-73.

[5] B.Chen et al (2020) Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II – Analytica Chima Acta, 2020 Aug 15:1125:279-287.

[6] Xiao-Chen Yuan and Ya-Xiong Tao (2022) Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin – Biomolecules, 2022 Oct; 12(10): 1407.

Why Choose Direct Peptides ?

Buy Melanotan II today and discover unrivalled quality with Direct Peptides , your premier source for Melanotan peptides. 


DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.