FOXO4-DRI Nasal Spray
This product is intended for research purposes only. To be used by trained professionals only.
FOXO4-DRI is a synthetic peptide that’s been gaining interest due to its potential senolytic properties, which means it has the ability to selectively induce death of senescent cells. Senescent cells are essentially aged or damaged cells that have lost their capacity to divide but remain metabolically active. They contribute to aging and age-related diseases, including hair loss..
The peptide works by disrupting the interaction between two proteins: FOXO4 and p53. Under normal conditions, FOXO4 interacts with p53 to prevent it from causing cell death, thereby allowing senescent cells to persist. However, when FOXO4-DRI is introduced, it competes with FOXO4 for binding to p53, effectively freeing up p53 to induce cell death in senescent cells .
In the context of age-related diseases, FOXO4-DRI’s senolytic action could potentially be harnessed to counteract conditions such as hair loss. Hair follicles, like all tissues, contain a population of stem cells that divide and differentiate to regenerate the tissue. However, as we age, these stem cells can become senescent and lose their regenerative capabilities, leading to hair thinning and eventual hair loss.
One study published investigated the effect of FOXO4-DRI nasal spray on bleomycin-induced pulmonary fibrosis in mice, showing that it could clear senescent cells and reverse the disease . This suggests that similar mechanisms might be at play in other tissues affected by senescence, such as hair follicles.
While no direct studies have yet demonstrated the effects of FOXO4-DRI on hair loss, the peptide’s ability to eliminate senescent cells makes it a promising candidate for future research in this area. Further studies are needed to fully understand and confirm the potential benefits of FOXO4-DRI nasal spray for hair loss.
 https://pubmed.ncbi.nlm.nih.gov/ 33996787/
 https://onlinelibrary.wiley.com/doi/ full/10.1111/jcmm.17333
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