SS-31 Elamipretide Nasal Spray

Description

SS-31 Elamipretide Nasal Spray

This product is intended for research purposes only. To be used by trained professionals only.

Elamipretide, also known as SS-31, is a synthetic tetrapeptide that has demonstrated substantial potential in the field of biomedicine. It belongs to a new class of therapeutics that selectively target mitochondria, the powerhouses of cells, to restore their function. This peptide is capable of penetrating cell and organelle membranes and is thought to interfere with the production of reactive oxygen species within the mitochondria, which can lead to improved physiological function [1].

Recent studies have shown that SS-31 Elamipretide nasal spray can improve mitochondrial dysfunction, synaptic impairment, and memory loss induced by lipopolysaccharides in mice [2]. This highlights the peptide’s potential as a therapeutic agent for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, where mitochondrial dysfunction is a key pathological feature.

One of the key molecular mechanisms of action of SS-31 is its interaction with membranes and its effect on surface electrostatics [3]. It binds selectively to cardiolipin, a phospholipid expressed exclusively on the inner mitochondrial membrane. Changes in cardiolipin have been associated with aging and multiple diseases, suggesting that SS-31 elamipretide nasal spray may have broad therapeutic applications.

Further research has demonstrated that SS-31 can modulate BAX recruitment and activation during apoptosis [4], thus potentially preventing cell death and promoting cellular health. Moreover, it has been found to attenuate age-associated post-translational modifications of heart proteins [5], suggesting its potential use in combating age-related cardiac diseases.

SS-31 elamipretide nasal spray has also been shown to improve ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator [1]. This points to its potential in treating age-related energetic decline at the cellular level.

References:

[1] https://link.springer.com/ article/10.1007/s11357-023-00861-y

[2] https://link.springer.com/ article/10.1186/s12974-019-1627-9

[3] https://www.biorxiv.org/ content/10.1101/735001v1.abstract

[4] https://link.springer.com/ article/10.1186/s13104-021-05613-9

[5] https://link.springer.com/ article/10.1007/s11357-021-00447-6

Sequence: d-Arg-Dmt-Lys-Phe-NH2

Molecular Formula: C32H49N9O5

Molecular Weight: 639.8 g/mol

Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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