FOXO4-DRI Pre Mixed Peptide 10mg
This product is intended for research purposes only. To be used by trained professionals only.
FOXO4-DRI pre mixed peptide is a synthetic peptide that has gained attention due to its possible senolytic capabilities, which implies it can selectively promote the death of senescent cells. Senescent cells are elderly or injured cells that have lost their ability to divide but are still metabolically active. They promote ageing and age-related disorders, such as hair loss.
The peptide operates by interfering with the interaction of two proteins: FOXO4 and p53. FOXO4 normally interacts with p53 to prevent it from inducing cell death, allowing senescent cells to survive. FOXO4-DRI pre mixed peptide, on the other hand, competes with FOXO4 for binding to p53, effectively freeing up p53 to initiate cell death in senescent cells .
FOXO4-DRI’s senolytic effect could potentially be used to treat disorders like hair loss in the setting of age-related diseases. Hair follicles, like all tissues, contain stem cells that divide and differentiate in order to rejuvenate the tissue. However, as we age, these stem cells become senescent and lose their ability to regenerate, resulting in hair thinning and eventual hair loss.
The effect of FOXO4-DRI nasal spray on bleomycin-induced pulmonary fibrosis in rats was explored in a study, which found that it could eliminate senescent cells and reverse the condition . This implies that comparable mechanisms may be at work in other tissues impacted by ageing, such as hair follicles.
While there have been no direct studies on the impact of FOXO4-DRI pre mixed peptide on hair loss, the peptide’s ability to eliminate senescent cells makes it an appealing choice for future research in this field.
 https://pubmed.ncbi.nlm.nih.gov/ 33996787/
 https://onlinelibrary.wiley.com/doi/ full/10.1111/jcmm.17333
Sequence: H-LTLRKEPASEIAQSILEAYSQNGW ANRRSGGKRPPPRRRQRRKKRG-OH
Molecular Formula: C228H388N86O64
Molecular Weight: 5358.05 g/mol
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