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PNC-27 Nasal Spray

£155.39£305.78

Buy PNC-27 Nasal Spray

PNC-27 is a synthesized anti-cancer peptide that inhibits HDM-2’s interaction with the tumour suppressor protein p53 by binding to it. According to scientific studies, it selectively destroys cancer cells by inducing membranolysis (collapse of the cell membrane).

PNC-27 15ml contains: 5mg
PNC-27 30ml contains: 10mg

Buy 10 and get 10% Discount

497 in stock

Description

PNC-27 Nasal Peptide Spray

This product is intended for research purposes only. To be used by trained professionals only.

PNC-27 is a peptide that has garnered attention within the scientific community for its potential anti-cancer properties. This membrane-active peptide contains an HDM-2-binding domain which corresponds to residues of p53, a protein known for its role in preventing cancer, and a transmembrane-penetrating sequence [1].

Research has shown that PNC-27 nasal spray induces tumour cell necrosis as the intact peptide. Studies have been conducted on a variety of breast cancer cells, such as MCF-7, MDA-MB-468 and MDA-MB-157, demonstrating that PNC-27 has the ability to induce these effects [1]. Further studies have also shown that PNC-27 binds to HDM-2 in cancer cells when treated with this peptide. For instance, one study incubated double-fluorophore-labelled PNC-27 (50 μg/ml) with 1 × 10^6 MIA-PaCa-2 cells for 4 hours, revealing significant interactions [2].

Additionally, PNC-27 has been explored as a potential tool for early cancer diagnosis. One study focused on PNC-27 peptide conjugated PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for the early diagnosis of cancer [3].

In vitro and in vivo studies have also been conducted to examine the efficacy of PNC-27 against colon adenocarcinoma and ovarian cancer. These studies have shown promising results, pointing to the potential of PNC-27 peptide as an efficient alternative treatment for these types of cancers [4].

However, it’s important to note that despite its promise, further research is needed to fully understand the potential benefits and risks of PNC-27 nasal spray.


References:

[1] https://link.springer.com/article/ 10.1007/s00280-009-1166-7

[2] https://www.pnas.org/doi/abs/ 10.1073/pnas.0909364107

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC9588323/

[4] https://www.sciencedirect.com/ science/article/abs/pii/S17732247 22000892


Molecular Formula: C188H293N53O44S

Molecular Weight: 4031.7

Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!

PNC-27 HPLC 2023 Certificates_DIRECT PEPTIDES

 

 

 

 

 

 

 

 


DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.


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