PNC-27 Nasal Spray

Description

PNC-27 Nasal Peptide Spray

This product is intended for research purposes only. To be used by trained professionals only.

PNC-27 is a peptide that has garnered attention within the scientific community for its potential anti-cancer properties. This membrane-active peptide contains an HDM-2-binding domain which corresponds to residues of p53, a protein known for its role in preventing cancer, and a transmembrane-penetrating sequence [1].

Research has shown that PNC-27 nasal spray induces tumour cell necrosis as the intact peptide. Studies have been conducted on a variety of breast cancer cells, such as MCF-7, MDA-MB-468 and MDA-MB-157, demonstrating that PNC-27 has the ability to induce these effects [1]. Further studies have also shown that PNC-27 binds to HDM-2 in cancer cells when treated with this peptide. For instance, one study incubated double-fluorophore-labelled PNC-27 (50 μg/ml) with 1 × 10^6 MIA-PaCa-2 cells for 4 hours, revealing significant interactions [2].

Additionally, PNC-27 has been explored as a potential tool for early cancer diagnosis. One study focused on PNC-27 peptide conjugated PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for the early diagnosis of cancer [3].

In vitro and in vivo studies have also been conducted to examine the efficacy of PNC-27 against colon adenocarcinoma and ovarian cancer. These studies have shown promising results, pointing to the potential of PNC-27 peptide as an efficient alternative treatment for these types of cancers [4].

However, it’s important to note that despite its promise, further research is needed to fully understand the potential benefits and risks of PNC-27 nasal spray.

References:

[1] https://link.springer.com/article/ 10.1007/s00280-009-1166-7

[2] https://www.pnas.org/doi/abs/ 10.1073/pnas.0909364107

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC9588323/

[4] https://www.sciencedirect.com/ science/article/abs/pii/S17732247 22000892

Molecular Formula: C188H293N53O44S

Molecular Weight: 4031.7

Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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