AMPK Peptide

Description

AMPK Peptide Vial

This product is intended for research purposes only. To be used by trained professionals only.

AMPK also known as Adenosine monophosphate (AMP)-activated protein kinase [1].

By increasing the AMP/ATP ratio during physical activity, AMPK is activated in human skeletal muscle and, according to animal studies, also in adipose tissue, liver, and perhaps other organs. The AMPK pathway is activated to maximise energy production, which promotes processes such as glucose uptake and fatty acid oxidation and decreases energy-consuming functions such as the synthesis of lipids and proteins [2].

Adenosine monophosphate (AMP)-activated protein kinase is emerging as a promising therapeutic target for the treatment of diabetes, metabolic syndrome, and CVD (cardiovascular disease), however, further research is needed [3].

The AMPK peptide, has been shown as a master energy sensor, and has been found to be overactivated in the brains of patients with neurodegenerative disorders, suggesting it could play a key role in these diseases. Research has shown that modulating the catalytic activity of AMPK can have neuroprotective effects, potentially linking its role to aging and the risk of developing neurodegenerative diseases. Additionally, activating AMPK could lead to changes in cellular metabolism and promotion of autophagy, making it a potential therapeutic target for diseases like Alzheimer’s and Parkinson’s [4].

The AMPK peptide has been observed to have significant anti-inflammatory properties. For instance, AMPK signalling appears to enhance energy metabolism and simultaneously repress inflammatory responses associated with chronic stress, such as nutritional overload [5]. Furthermore, activation of AMPK has been found to attenuate inflammatory pain by inhibiting the level of proinflammatory cytokine IL-1β in inflamed skin, suggesting its potential role in pain management. Additionally, AMPK activation has been shown to suppress vascular inflammation, further supporting its role as a potential therapeutic target in managing inflammatory diseases [6].

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References:

[1] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC5780224/

[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2779044/

[3] https://pubmed.ncbi.nlm.nih.gov/ 30710062/

[4] https://www.sciencedirect.com/ science/ article/pii/S0021925820873062

[5] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3111671/

[6] https://diabetesjournals.org/diabetes/ article/64/12/4285/34746/AMPK-Suppresses-Vascular-Inflammation-In-Vivo-by

Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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