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AMPK Peptide

£17.84£97.63

Buy AMPK Peptide Vial

The heterotrimeric complex AMP-activated protein kinase is a sensor of cellular energy levels. Activating AMPK is essential for regulating metabolic activities in the heart, liver, skeletal muscle, pancreas, and adipose tissue.

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Description

AMPK Peptide Vial

This product is intended for research purposes only. To be used by trained professionals only.

AMPK also known as Adenosine monophosphate (AMP)-activated protein kinase [1].

By increasing the AMP/ATP ratio during physical activity, AMPK is activated in human skeletal muscle and, according to animal studies, also in adipose tissue, liver, and perhaps other organs. The AMPK pathway is activated to maximise energy production, which promotes processes such as glucose uptake and fatty acid oxidation and decreases energy-consuming functions such as the synthesis of lipids and proteins [2].

Adenosine monophosphate (AMP)-activated protein kinase is emerging as a promising therapeutic target for the treatment of diabetes, metabolic syndrome, and CVD (cardiovascular disease), however, further research is needed [3].

The AMPK peptide, has been shown as a master energy sensor, and has been found to be overactivated in the brains of patients with neurodegenerative disorders, suggesting it could play a key role in these diseases. Research has shown that modulating the catalytic activity of AMPK can have neuroprotective effects, potentially linking its role to aging and the risk of developing neurodegenerative diseases. Additionally, activating AMPK could lead to changes in cellular metabolism and promotion of autophagy, making it a potential therapeutic target for diseases like Alzheimer’s and Parkinson’s [4].

The AMPK peptide has been observed to have significant anti-inflammatory properties. For instance, AMPK signalling appears to enhance energy metabolism and simultaneously repress inflammatory responses associated with chronic stress, such as nutritional overload [5]. Furthermore, activation of AMPK has been found to attenuate inflammatory pain by inhibiting the level of proinflammatory cytokine IL-1β in inflamed skin, suggesting its potential role in pain management. Additionally, AMPK activation has been shown to suppress vascular inflammation, further supporting its role as a potential therapeutic target in managing inflammatory diseases [6].

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References:

[1] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC5780224/

[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2779044/

[3] https://pubmed.ncbi.nlm.nih.gov/ 30710062/

[4] https://www.sciencedirect.com/ science/ article/pii/S0021925820873062

[5] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3111671/

[6] https://diabetesjournals.org/diabetes/ article/64/12/4285/34746/AMPK-Suppresses-Vascular-Inflammation-In-Vivo-by


Storage: Lyophilized peptides stored below -18°C.

Research use only. Not for human or animal consumption!

AMPK HPLC 2023 Certificates_DIRECT PEPTIDES

 

 

 

 

 

 

 

 


DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.


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