FTPP – Fat Targeted Proapoptotic Peptide
Are you worried about your weight? Why not try reversing your obesity by targeted ablation using an adipose tissue? Obesity is a condition that is becoming prevalent in developed societies.
In this article, you will find out about an anti-obesity peptide. Called FTPP – Fat Targeted Proapoptotic Peptide. FFTP’s based on the targeted induction of apoptosis within the adipose tissue’s vasculature.
What is Adipotide or FTPP ?
FTPP is an experimental fat loss peptidomimetic with CKGGRAKDC-GG-(KLAKKLAK) amino acid sequence. In addition, American researchers developed FTPP in their efforts to combat obesity.
What are peptidomimetics? They are small protein-like chains with the role of mimicking a peptide. They’re developed to fight obesity, FTPP’s shown to reduce a treated monkey’s weight by 11%. FTPP reduced the monkey’s fatty tissue, waist circumference, and BMI.
Many clinical studies conducted on Adipotide. The researchers show FTPP to have the ability to kill fat cells. As a result, it can cut down the subcutaneous fat’s mass and volume. As a result, the body experiences significant weight loss.
How does FTPP help to lose weight?
It can kill fat cells or adipocytes by causing the blood vessels. That supply adipocytes to undergo apoptosis or programmed cell death. This results in nutrient deprivation, which causes starvation.
It results to decrease in cell size or cellular atrophy. As well as the adipocytes having a buildup of waste products. When an irreparable injury happens; the mitochondria will release caspases. Protease enzymes, instigating the apoptotic process.
The carcasses also activate the DNA’s used in creating mRNA, which called transcription.
Additionally, another process activated is a translation. The MRNA’s form the nascent primary peptide. When transcription and translations activated. It will lead to protein production that affects the apoptotic process.
There were molecular studies about Adipotide. And they revealed this particular peptide to have a distinct stereochemical (3D) conformation.
The unique conformation of Adipotide is what allows it to bind to two receptors only. Adipotide can only bind to prohibitin and ANXA-2. Both of these receptors found on the endothelium’s surface. The endothelium is the blood vessel’s innermost lining.
The blood vessels supply the white adipocytes. Which means the receptors deliberate tissue adipotide’s tissue specificity.
When consumption of energy extends the use of energy. That’s when white adipocytes form and accumulate, which is a mark of obesity.
Who is not aware of the dangers of obesity? It’s a risk factor for many diseases, including hypertension, cancer, endocrine disorders, degenerative diseases, cardiovascular diseases, and many more.
Additionally, when white adipocytes accumulate, the affected individual becomes predisposed to lipoma and lipomatosis. Abdominal adiposity is one of the most active forms of adiposity, which causes white adipocytes.
Studies on FTPP
There are many studies conducted on adipotide, some of which were by Mikhail G Kolonin, et al. Their studies reveal that adipotide can induce the apoptosis of the white adipocytes’ vascular bed mice. The result of this is the normalization of the mice’s metabolic processes.
Kirstin F. Barnhart et al. conducted a related study. This time, the study done on monkeys. It showed that when the white adipocytes’ vascular bed undergoes an adipotide induced selective apoptosis, the result is weight loss as well as normalization of insulin function.
Adipotide or FTPP is an experimental treatment used to combat weight loss by preventing the blood supply from going too fat cells. In clinical trials, it has helped obese monkeys to lose around 11% body weight in only four weeks.
These results might open a way for human therapy based on the outcome of recent clinical research. Therefore if used for weight loss, the formulas injected to induce the death of fat cells.
The end of fat cells will result in your body losing significant volume and mass of fat, triggering weight loss. Therefore many people believe Adipotide as the way to a stress-free fat loss.
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