FTPP – Fat Targeted Proapoptotic Peptide – Diect Peptides
Are you worried about your weight? Why not try reversing your obesity by targeted ablation using an adipose tissue? Obesity is a condition that is becoming increasingly prevalent in developed societies.
The health sector has progressed significantly in understanding the molecular mechanisms that lead to obesity. However, the fact remains that there is not a safe and effective treatment found as of yet.
In this article, you will find out about an anti-obesity therapy called FTPP – Fat Targeted Propoptotic Peptide. FFTP is based on targeted induction of apoptosis within the adipose tissue’s vasculature.
What is Adipotide or FTPP ?
Adipotide or FTPP, also known as fat targeted propoptotic peptide, is an experimental fat loss peptidomimetic with CKGGRAKDC-GG-(KLAKKLAK) amino acid sequence. American researchers developed FTPP in their efforts to combat obesity.
What are peptidomimetics? They are small protein-like chains with the role of mimicking a peptide. Developed to fight obesity, FTPP is shown to reduce a treated monkey’s weight by 11%. FTPP reduced the monkey’s fatty tissue, waist circumference, and BMI.
Many clinical studies were conducted concerning Adipotide. The researchers show FTPP to have the ability to kill fat cells. Therefore, it can cut down the subcutaneous fat’s mass and volume. As a result, the body experiences significant weight loss.
How does Adipotide help to lose weight? It can kill fat cells or adipocytes by causing the blood vessels that supply adipocytes to undergo apoptosis or programmed cell death. This results in nutrient deprivation, which subsequently causes starvation.
In turn, it results to decrease in cell size or cellular atrophy as well as the adipocytes having a buildup of waste products. When an irreparable injury happens, the mitochondria will release caspases, protease enzymes instigating the apoptotic process.
The carpases also activates a process where the DNA is used in creating mRNA, which is called transcription. Additionally, another process activated is the translation, which means the mRNA is utilized in forming the nascent primary peptide.
When transcription and translation are activated, it will eventually lead to protein production that affects the apoptotic process. There were molecular studies regarding Adipotide, and they revealed this particular peptide to have a distinct stereo-chemical (3D) conformation.
The unique conformation of Adipotide is what allows it to bind to two receptors only. Adipotide can only bind to prohibitin and ANXA-2. Both of these receptors are found on the endothelium’s surface. The endothelium is the blood vessel’s innermost lining.
The blood vessels supply the white adipocytes, which mean the receptors deliberate tissue adipotide’s tissue specificity. When consumption of energy extends the utilization of energy, that’s when white adipocytes form and accumulate, which is a mark of obesity.
Who is not aware of the dangers of obesity? It’s a risk factor for numerous diseases, including hypertension, cancer, endocrine disorders, degenerative diseases, cardiovascular diseases, and many more.
In addition, when white adipocytes abnormally accumulate, the affected individual becomes predisposed to lipoma and lipomatosis. Abdominal adiposity is one of the most lipolytically active forms of adiposity, which is mainly caused by white adipocytes.
Studies on Adipotide
There are many studies conducted on adipotide, some of which were by Mikhail G Kolonin, et al. Their studies reveal that adipotide can induce the apoptosis of the white adipocytes’ vascular bed, specifically in mice. The result of this is the normalization of the mice’s metabolic processes.
Kirstin F. Barnhart et al. conducted a related study. This time, the study is done on monkeys. It showed that when the white adipocytes’ vascular bed undergoes an adipotide induced selective apoptosis, the result is weight loss as well as normalization of insulin function.
Adipotide and Weight Loss
Adipotide or FTPP is an experimental treatment used to combat weight loss by preventing the blood supply to go to fat cells. In clinical trials, it has effectively helped obese monkeys to lose around 11% body weight in only four weeks.
These results might open a way for human therapy based on the outcome of recent clinical research. The study was published in Science Translational Medicine and revealed the significant reduction in the waist circumference and mass index of the treated monkeys.
If used for weight loss, the formula is injected to induce the death of fat cells. The end of fat cells will result in your body losing significant volume and mass of fat, triggering weight loss. Many people believe Adipotide as the way to a stress-free fat loss.