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AICAR Benefits

AICAR Benefits from Direct Peptides

AICAR, short for 5-aminoimidazole-4-carboxamide ribonucleoside, is a naturally occurring substance that plays a significant role in energy balance and various metabolic pathways. It’s an allosteric activator of AMP-activated protein kinase (AMPK), a protein involved in cellular energy homeostasis. In the athletic world, AICA Ribonucleotide has been noted for its potential to improve performance, although it’s considered a prohibited substance [1]. It’s also used widely in research due to its ability to modulate role of AMPK signalling with Athletes using it for performance-enhancing in sports where they need endurance.

The History of AICAR

In the medical world, AICAR has been used to restrict ischemia or the tissues’ blood supply. In early studies in the 1980s, it played an important role in preserving the heart’s blood flow. AICAR has also shown promise when it comes to treating diabetes because of its capability of increasing the tissues’ metabolic ability, which it does by modifying the muscle’s composition.

How AICAR Works

Clinical studies have shown when AICAR triggers AMPK, it leads to the skeletal muscle cells up take in glucose. In the independent experiments conducted by the Salk Institute and Howard Hughes Medical Centre, mice given the AICAR peptide were able to run by an increase of 44% without needing to train. It’s not surprising that when athletes heard about this compound, they began to use it without fearing testing or regulation up until 2011.

Check out AICAR peptides from Direct Peptides.

Potent Endurance Stacking with AICAR and GW-501516

AICAR and GW-501516 (also known as Cardarine) are often used together in research because they have complementary effects on energy metabolism. AICA Ribonucleotide, in the role of AMPK activator, stimulates glucose uptake and fatty acid oxidation, while GW-501516 acts on the peroxisome proliferator-activated receptor delta (PPARδ) to increase endurance and metabolic rate [2]. This combination could potentially enhance physical performance and aid in weight loss, although it’s important to note that both substances are on the World Anti-Doping Agency’s prohibited list. Moreover, while these substances show promise in preclinical studies, their long-term safety and efficacy in humans are not fully established, and thus they should be used with caution.

Is it Safe for Female Test Subjects to Use AICAR and GW?

Given that both are not hormone compounds, it is believed that females can use the compounds without virilization effects. Using AICAR helps to attack fat stores as well as increase the body’s fatty acid metabolism so that exercise pays off in helping you lose weight.

Dosage of AICAR

The dosages for AICAR for research purposes can differ depending on the physique of the subject. It is important to research the recommended dosage of any peptide before utilising it in your research to optimise it’s beneficial effects.

AICAR Studies

This peptide is known for its incredible effect on increasing endurance levels and burning fat. Many studies show this peptide often researched on rodent subjects results showed the peptide to induce metabolic genes. It’s capable of improving one’s running endurance significantly. This peptide can do enhance endurance by transforming fast-twitch muscle fibres into becoming a fat-burning, more energy-efficient, slow-twitch fibres.

AICAR, a ribonucleoside, has shown potential in the treatment of various forms of Leukaemia. Studies have demonstrated that it can induce apoptosis, or programmed cell death, in chronic lymphocytic leukaemia (CLL) cells, providing an alternative therapeutic option for patients with impaired p53 function [3]. Moreover, AICAR has been found to suppress cell proliferation and enhance sensitivity of other leukaemia types to treatment, suggesting its possible role in targeted therapy.

Furthermore, the peptide has shown potential in the treatment and management of diabetes. Studies suggest that long-term administration  can improve glucose tolerance and lipid profile, potentially helping to manage symptoms of type 2 diabetes [4]. Moreover, AICA Ribonucleotide peptide treatment has been found to increase insulin-stimulated glucose uptake and reduce hepatic glucose output, indicating its therapeutic potential for insulin resistance and blood glucose regulation

By far the most common use of the AICA Ribonucleotide peptide is by bodybuilders and athletes for improving their endurance and performance. Many bodybuilders interested in the peptide for it’s incredible fat-burning capabilities. As for athletes, they often use this particular peptide for endurance sports believing it will help increase their endurance levels.


The products mentioned in this posts intended for research and medical purposes only, to be only used by trained professionals.


[1] https://pubmed.ncbi.nlm.nih.gov/ 34064363/

[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2706130/

[3] https://pubmed.ncbi.nlm.nih.gov/ 20664053/

[4] https://pubmed.ncbi.nlm.nih.gov/ 15793229/

DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.

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