PTD-DBM Nasal Spray
This product is intended for research purposes only. To be used by trained professionals only.
PTD-DBM is a specialized peptide that is known for its ability to activate the Wnt/β-catenin signalling pathway. This activation is achieved by interfering with the binding of CXXC5, a negative regulator of this pathway, and Dishevelled (Dvl), an upstream molecule. PTD-DBM has drawn significant attention for its potential in regenerative medicine, particularly in the area of hair loss treatment and wound healing .
The peptide has been found to inhibit the follicle shrinking action caused by the body’s hormones and enzymes, thereby promoting hair regeneration. Studies have shown that treatment with PTD-DBM stimulates hair regrowth and wound-induced hair neogenesis . Additionally, it was observed that suppression of neogenic hair growth by PGD2, a prostaglandin involved in the regulation of hair growth, could be overcome by PTD-DBM nasal spray treatment .
In the context of wound healing, PTD-DBM nasal spray has demonstrated promising results as well. Research has shown that the peptide can enhance the wound healing process, presumably due to its role in activating the Wnt/β-catenin signaling pathway . It was also found that the application of PTD-DBM peptide for more than six months had beneficial effects on cutaneous wound healing .
However, the use of PTD-DBM is not without its limitations. The peptide’s routine application is limited due to factors such as cost and stability. Therefore, research is ongoing to discover small molecules that can mimic the effects of PTD-DBM, which could potentially provide a more cost-effective and stable alternative .
 https://www.sciencedirect.com/ science/article/pii/S0022202X 17315555
 https://www.mdpi.com/2073-4409/ 12/4/555
 https://rupress.org/jem/article/ 212/7/1061/41854/The-Dishevelled-binding-protein-CXXC5-negatively
 https://www.mdpi.com/1422-0067/ 24/14/11742
 https://bpspubs.onlinelibrary. wiley.com/doi/full/10.1111/bph. 15438
Sequence: RRRRRRRRGGGGR KTGHQICKFRKC
Molecular Formula: C124H22N61O28S2
Molecular Weight: 3082.65
Storage: Lyophilized peptides stored below -18°C.
Research use only. Not for human or animal consumption
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