Buy MOTS-C Peptide
MOTS-c, also known as Mitochondrial-Derived Peptide MOTS-c, is a novel peptide that has been shown to have significant implications in the field of biochemistry and medical research. It is a 16 amino acid peptide encoded in the mitochondria, specifically within the 12S rRNA gene.
Research on MOTS-c has illuminated its role in regulating metabolic homeostasis. This peptide has been found to enhance glucose uptake and fatty acid oxidation in skeletal muscle, thereby improving insulin sensitivity and overall metabolic health. It can potentially be used to combat metabolic disorders such as diabetes and obesity.
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New Reduced Price
New Reduced Price
Mots-C Peptide Vial
£29.79 – £38.77 This product has multiple variants. The options may be chosen on the product page -
Mots-C Nasal Spray
£37.79 – £70.58 This product has multiple variants. The options may be chosen on the product page -
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Mots-c 10mg Pre Mixed
£32.37 – £87.40 This product has multiple variants. The options may be chosen on the product page
What Is MOTS-C?
Mitochondria, often referred to as the “powerhouses of cells,” are organelles responsible for processing nutrients, breaking them down, and generating the energy necessary for cellular activities. These structures are crucial not only for energy production but also for cellular communication via molecular signals.
Among the peptides derived from mitochondria, MOTS-c, originating from a short open reading frame (sORF) within the mitochondrial genome, stands out due to its substantial role in metabolic functions, such as glucose metabolism, muscle synthesis, and maintaining energy balance.
This sORF-derived peptide enables MOTS-c to perform vital tasks in metabolic regulation and cellular adaptation. Its capability to enhance insulin sensitivity and boost metabolic balance has made it a focal point in research, especially concerning metabolic diseases and conditions related to aging.
Currently, its therapeutic potential is under investigation for diseases like obesity, diabetes, and metabolic syndrome, underlining its importance in the advancement of medical treatments and metabolic research.
The Mechanism Of Action of MOTS-C Peptide
The mechanism of action of mots-c peptide involves its interaction with cell signaling pathways that control energy metabolism and stress response. Mots-c activates the AMP-activated protein kinase (AMPK) pathway, a key energy sensor in cells, which improves glucose uptake and boosts insulin sensitivity.
By activating AMPK, mots-c affects the expression of genes related to mitochondrial function and energy use, promoting efficient energy consumption and oxidative metabolism. Additionally, mots-c influences the folate cycle, crucial for nucleotide synthesis and repair, by increasing levels of 5-methyltetrahydrofolate.
This adjustment helps cells adapt to metabolic stress and supports improved metabolic resilience. Overall, mots-c’s mechanism highlights its potential to address metabolic issues by regulating important pathways that affect energy balance and cellular stress responses.
Structure of MOTS-C
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 f/mol
PubChem CID: 146675088
What Are The Research Benefits of MOTS-C?
Insulin Sensitizer: Mots-c is a mitochondrial-derived peptide (MDP) that has gained significant attention in recent research for its potential health benefits. Studies have demonstrated that Mots-c can enhance insulin sensitivity, which is crucial for effective glucose metabolism in the body. By improving how our cells respond to insulin, Mots-c may help regulate blood sugar levels more efficiently, thereby potentially reducing the risk of developing type 2 diabetes. This peptide represents a promising avenue for therapeutic strategies aimed at managing insulin resistance and promoting metabolic health [1].
Obesity Management: Mots-c contributes to obesity management by enhancing metabolic efficiency and energy expenditure. Research indicates that mots-c can influence pathways like AMPK involved in fat metabolism, thus promoting the breakdown of fats and reducing lipid accumulation in adipose tissue. This leads to improved weight management and decreased risk of obesity-related health complications. The peptide’s ability to support energy homeostasis highlights its potential role in developing treatments for obesity [1].
Promotes Metabolic Homeostasis: Research indicates that Mots-c regulates metabolic processes at the cellular level, promoting homeostasis and potentially protecting against metabolic disorders [2].
Exercise Mimetic: Recent studies have shown that Mots-c, a peptide discovered in muscle tissue, has the ability to mimic certain effects of exercise. This includes enhanced endurance and increased fat burning, which are crucial for maintaining overall health and wellbeing. By activating various metabolic pathways similar to those engaged during physical activity, Mots-c could potentially offer a valuable alternative for individuals who are unable to engage in traditional exercise due to health issues or time constraints. Its ability to positively influence metabolic health and promote fitness-related benefits highlights its potential as a significant contributor to an active lifestyle [3].
Muscle Metabolism and Physical Performance: MOTS-C has important implications for muscle health by enhancing muscle metabolism and mitigating oxidative stress. This peptide’s role in regulating transcription and gene expression processes within muscle cells helps defend against apoptosis, thus preserving muscle integrity. Enhanced muscle resilience contributes to improved physical performance, making MOTS-C a promising area of research for understanding and optimizing muscle function [4].
Anti-aging and Longevity: Given its vital role in maintaining metabolic balance and promoting cellular resilience, MOTS-C presents significant potential for addressing age-related health decline. This peptide functions by enhancing mitochondrial function and regulating energy metabolism, which are crucial for overall health as we age. Investigating its effects on aging processes could lead to groundbreaking discoveries in the field of gerontology, potentially offering new strategies for the prevention and management of age-associated diseases such as Alzheimer’s, cardiovascular disorders, and metabolic syndromes. By understanding how MOTS-C interacts with cellular pathways involved in aging, researchers may unlock new avenues for improving healthspan and longevity [5].
Place in Scientific Research: Mots-c is part of an emerging field of research into mitochondrial-derived peptides, which are believed to play crucial roles in health, disease, and ageing. Understanding these peptides could revolutionize our approach to treating a variety of diseases [6].
Bone Health: MOTS-C has shown promise in fighting bone loss by affecting pathways linked to bone metabolism. Studies indicate that this peptide could help maintain bone density and strength, which is important for lowering the risk of osteoporosis and other bone-related issues. Its impact on cellular energy and stress responses may aid bone health by improving the regeneration and repair processes needed to keep bones strong [7].
Cardiovascular Health: MOTS-C is a peptide that activates pathways involved in stress response and energy homeostasis, suggesting it may have a significant role in promoting cardiovascular health. By influencing cellular processes related to metabolism and stress resistance, MOTS-C could help enhance heart function and improve resilience against various forms of metabolic stress. Ongoing research into its effects on the cardiovascular system may provide valuable insights, potentially leading to groundbreaking advancements in the prevention and treatment of cardiovascular diseases. Understanding how MOTS-C affects heart health could open new avenues for therapeutic interventions, aiming to reduce the incidence of heart-related conditions and enhance overall well-being [8].
Antibacterial Potential: A 2017 study explored the mitochondrial-derived peptide MOTS-c as a treatment for Methicillin-resistant Staphylococcus aureus (MRSA) infections in mice. The results showed that MOTS-c significantly improved survival rates and reduced bacterial load in infected mice. These findings suggest that MOTS-c may have antimicrobial properties, indicating its potential as a new therapeutic option for challenging MRSA infections and highlighting the need for further research into its mechanisms and clinical applications [9].
Neuroprotection and Cognitive Health: Recent studies investigating the effects of MOTS-C on mitochondrial function have revealed promising implications for cognitive health and neuroprotection. Mitochondria play a crucial role in cellular energy production, and their dysfunction is often linked to various neurological conditions. By exploring how MOTS-C influences mitochondrial efficiency, researchers aim to uncover potential strategies for preventing or mitigating the effects of neurological diseases such as Alzheimer’s and Parkinson’s, as well as age-related cognitive decline. The insights gained from this research could pave the way for developing novel therapeutic approaches that enhance brain health and improve quality of life for aging populations [10].
Buy MOTS-C Pre Mixed Peptide Pen for research online today!
Buy MOTS-C Peptide Nasal Spray
Buy MOTS-C nasal spray, an innovative and convenient option for exploring the physiological effects of the MOTS-C peptide in metabolic research.
The nasal spray facilitates effective administration through its rapid absorption into the bloodstream, allowing for quicker biological activity compared to traditional delivery methods.
Available in 15ml and 30ml, it ensures ease of use and eliminates the need for injections, thereby increasing user compliance in research settings.
The increasing interest in MOTS-C nasal spray includes its potential applications in studying metabolic regulation, insulin sensitivity, and energy balance. As research uncovers more about MOTS-C’s therapeutic benefits, this nasal spray is becoming a valuable tool for metabolic and age-related studies.
Buy MOTS-C nasal spray online and discover the benefits of this transformative peptide for your scientific work.
Frequently Asked Questions (FAQs) about MOTS-C
Is MOTS-C legal to use and purchase?
MOTS-C is available for research purposes and is not approved by the United States Food and Drug Administration (FDA) for medical use in humans.
However, it is legal to buy MOTS-C for scientific investigation and study. As always, it is crucial for researchers to comply with local laws and regulations when purchasing and using research-grade peptides.
At Direct Peptides, we ensure that our MOTS-C products are of the highest quality, supporting your research endeavors with precision and reliability.
Are there any known side effects associated with MOTS-C?
Current animal studies show a favorable safety profile for MOTS-C, but human-specific side effects are not well-documented yet. Researchers continue to investigate its long-term safety and possible adverse effects.
How can MOTS-C be administered?
MOTS-C is available in various formulations, including injectable vials, nasal sprays, and pre-mixed peptide pens, allowing researchers to select the most appropriate method for their studies.
What are the recommended dosages for MOTS-C?
As MOTS-C is primarily used for research purposes, specific dosing recommendations for human use are not established. Doses may vary based on the study design and research focus, highlighting the importance of professional guidance.
Where is the best place to buy MOTS-C peptides?
Direct Peptides is a trusted supplier of premium-quality peptides, offering tracked shipping and guaranteed delivery. Buy MOTS-C peptides with 99% purity from us to ensure the reliability and precision essential for your advanced research studies. With our diverse range of formulations and dedicated customer support, we make it effortless to find the perfect product for your research needs and budget.
Summary of Research Applications
- Improves mitochondrial function
- Potential for anti-aging benefits, including increased longevity
- Boosts energy levels
- Promotes insulin sensitivity
- Supports weight loss and enhances fat burning.
- Protects against muscle wasting
- Enhances bone strength to reduce the risk of osteoporosis
- Supports neuroprotection against cognitive decline and conditions like Alzheimer’s disease.
Buy MOTS-C 10mg Peptide Vial from Direct Peptides
MOTS-C Peptide Quality Assured
At Direct Peptides , we focus on delivering top-quality peptide solutions, offering MOTS-C peptides with a guaranteed purity of 99%. Each batch goes through a careful synthesis process to ensure our products meet or exceed industry quality and effectiveness standards.
This commitment to high purity reinforces our leadership in the peptide industry and maximizes the therapeutic potential of MOTS-C. We ensure researchers receive a reliable product tailored to their specific needs, helping them conduct advanced studies and innovative applications.
When you choose to buy MOTS-C from us, you gain access to a high-quality compound that boosts your research capabilities and provides valuable insights.
References For Further Reading
[1] C Lee, J Zeng, B G. Drew, T Sallam, A Martin-Montalvo, et al (2015) The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance – Cell Metabolism, 2015 Mar 3, Volume 21 (Issue 3), Pages 443–454.
[2] S J Kim, J Xiao, J Wan, P Cohen, and K Yen (2017) Mitochondrially derived peptides as novel regulators of metabolism – The Journal of Physiology, 2017 Nov 1, Volume 595 (Issue 21), Pages 6613–6621.
[3] X Tong, X Chen, S Zhang, M Huang, X Shen, et al (2019) The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis – Biomed Research International, 18 April 2019, Volume 2019, Page 8171897.
[4] Y Zheng, Z Wei, and T Wang (2023) MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation – Frontiers in Endocrinology (Lausanne), 25 January 2023, Volume 14, Page 1120533.
[5] Su-Jeong Kim,1 Hemal H. Mehta,1 Junxiang Wan,1 Chisaka Kuehnemann (2018) Mitochondrial peptides modulate mitochondrial function during cellular senescence – Impact Jounral on Aging (Albany NY). 2018 Jun, Volume 10 (Issue 6), Pages 1239–1256.
[6] K Yen, H H. Mehta, S J Kim, Y H Lue, J Hoang, et al (2020) The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan – Impact Journal on Aging (Albany NY), 2020 Jun 30, Volume 12 (Issue 12), Pages 11185–11199.
[7] N Che, W Qiu, J-K Wang, X-X Sun, L-X Xu, R Liu, and L Gu (2019) MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway – European Review for Medical and Pharmacological Sciences, 2019 Apr, Volume 23 (Issue 8), Pages 3183-3189.
[8] Q Qin, S Delrio, J Wan, R. J Widmer, P Cohen, et al (2018) Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction – International Journal of Cardiology, Volume 254, 1 March 2018, Pages 23-27.
[9] D Zhai, Z Ye, Y Jiang, C Xu, B Ruan (2018) MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA – Molecular Immunology, Volume 92, December 2017, Pages 151-160.
[10] H Lu, S Tang, C Xue, Y Liu, J Wang, et al ( 2019) Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation – International Journal of Molecular Sciences, 2019 May, Volume 20 (Issue 10), Page 2456.
Why Choose Direct Peptides ?
Buy MOTS-C today and discover top-quality products from Direct Peptides, your go-to source for mitochondrial-derived peptides. What sets us apart is our range of MOTS-C formulations, including 10mg peptide vials and a kit with bacteriostatic water and syringes. We also provide peptide nasal sprays in 15ml and 30ml bottles, as well as pre-mixed peptide pens. We cater to various research needs, ensuring that researchers have the exact formulation they need for their projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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