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Mots-C Nasal Spray

£36.74£68.48

Buy MOTS-c Nasal Spray

MOTS-c is a mitochondrial-encoded peptide consisting of 16 amino acids, which is encoded from the 12S rRNA region of the mitochondrial genome. This peptide plays a crucial role in promoting metabolic homeostasis, largely through the activation of AMPK and by directly regulating metabolic functions across the body.

Mots-c Peptide 15ml contains: 10mg
Mots-c Peptide 30ml contains: 20mg

Buy 10 and get 10% Discount

564 in stock

Description

MOTS-c Nasal Spray

This product is intended for research purposes only. To be used by trained professionals only.

MOTS-c nasal spray peptide, is a novel mitochondrial-derived peptide, that has emerged as a significant regulator of metabolic homeostasis, particularly in muscle and fat metabolism. Comprising 16 amino acids, MOTS-c targets the skeletal muscle and enhances glucose metabolism, making it a key player in metabolic regulation [1].

MOTS-c has also been implicated in longevity, with certain polymorphisms located in the MOTS-c encoding region possibly contributing to exceptional lifespan [2]. This peptide’s potential role in aging and age-related diseases is attracting increasing interest from the scientific community [3]. Moreover, recent research has highlighted the therapeutic potential of MOTS-c nasal spray. It has been shown to increase survival and decrease bacterial load in mice infected with MRSA, enhancing the bactericidal capacity of macrophages [4]. This could suggest a broader role for MOTS-c in immune function and infection control.

In terms of therapeutic exploitation, MOTS-c translation occurs exclusively in the cytoplasm, and its sequence, especially the first 11 residues, is highly conserved. This could have implications for drug development and disease treatment strategies. Furthermore, MOTS-c has been shown to regulate adipose homeostasis, thereby preventing metabolic dysfunction induced by ovariectomy [5]. This peptide’s effect on the insulin signalling pathway could make it an attractive target for interventions aimed at metabolic disorders.

Notably, MOTS-c nasal spray administration has been demonstrated to protect against adverse remodelling and dysfunction of the heart under pressure overload conditions, suggesting a possible role in cardiovascular health. Interestingly, MOTS-c can translocate to the nucleus to regulate nuclear gene expression in response to metabolic stress [6]. This property highlights the peptide’s potential as a regulator of cellular processes beyond metabolism.


References:

[1] https://www.sciencedirect.com/ science/article/abs/pii/S08915849 16302507

[2] https://onlinelibrary.wiley.com/ doi/full/10.1111/acel.12389

[3] https://www.mdpi.com/1422-0067/ 23/19/11991

[4] https://www.sciencedirect.com/ science/article/abs/pii/S01615890 17305461

[5] https://link.springer.com/article/ 10.1007/s00109-018-01738-w

[6] https://www.cell.com/cell-metabolism/ pdf/S1550-4131(18)30390-5.pdf


Sequence:Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular Formula: C101H152N28O22S2

Molecular Weight: 2174.64 f/mol

Storage: Lyophilized peptides to be stored below -18°C

Research use only. Not for human or animal consumption!

MOTS-C HPLC 2023 Certificates_DIRECT PEPTIDES

 

 

 

 

 

 

 

 


DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.


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