Buy KPV Peptide
Buy KPV peptide, a short bioactive peptide known for its anti-inflammatory and healing properties, often studied for its potential therapeutic applications in conditions like skin disorders and inflammatory diseases.
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BPC-157 KPV Nasal Stack
£41.13 – £73.26 This product has multiple variants. The options may be chosen on the product page -
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BPC-157 KPV Peptide Stack
£22.59 – £31.57 This product has multiple variants. The options may be chosen on the product page -
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KPV Pre-Mixed 2mg Peptide
£20.45 – £55.21 This product has multiple variants. The options may be chosen on the product page -
KPV Nasal Spray
£26.24 – £47.48 This product has multiple variants. The options may be chosen on the product page -
KPV
£13.64 – £22.62 This product has multiple variants. The options may be chosen on the product page
What Is KPV?
KPV peptide is a small molecule composed of three amino acids: lysine (K), proline (P), and valine (V). It is known for its anti-inflammatory and healing properties, helping reduce inflammation and support tissue repair. This makes it a potential treatment for conditions like inflammatory bowel disease and other inflammation-related disorders.
Studies, including those using animal models of IBD, have shown that it can lower intestinal inflammation and help restore normal colon length without causing harmful side effects. Researchers are continuing to study how it works and its efficacy, with the hope of using it to address complex medical issues.
KPV Mechanism Of Action
The tripeptide works by targeting key pathways in the body’s inflammatory response. It helps reduce inflammation by inhibiting pro-inflammatory cytokines—molecules responsible for promoting inflammation. KPV specifically interacts with the melanocortin-1 receptor (MC1R), which plays a role in reducing inflammation and supporting tissue repair.
By binding to MC1R, KPV lowers inflammatory signals and minimizes tissue damage. This process reduces inflammation without completely suppressing the immune system, making KPV a promising option for conditions like IBD, where chronic inflammation is a major issue. Researchers are continuing to study these mechanisms to fully explore KPV’s potential in medicine.
Structure of KPV Peptide
Sequence: H-Lys-Pro-Val-OH
Molecular Formula: C16H30N404
Molecular Weight: 342.43 g/mol
PubChem CID: 125672
What Are The Research Benefits of KPV
Anti-Inflammatory: It has demonstrated strong anti-inflammatory effects across various systems, including the gastrointestinal tract, central nervous system, vascular system, joints, and acute lung injury [1]. It has strong anti-inflammatory effects by blocking pro-inflammatory cytokines, which are key contributors to chronic conditions like inflammatory bowel disease (IBD).
Professor Didier Merlin’s research shows that KPV interacts with the PepT1 transporter in intestinal and immune cells to block the NF-kappaB and MAP kinase pathways, reducing cytokine production and regulating inflammation [2]. In mouse colitis models (DSS and TNBS), oral KPV significantly lowered inflammation and cytokine levels, resulting in less colonic infiltration and normal colon lengths compared to controls [3]. These findings suggest KPV could be a potential treatment for inflammatory bowel disease [4].
Wound Healing: Research shows that alpha-MSH analogs, like KPV, reduce inflammation in various conditions, including dermatitis, arthritis, and gastrointestinal inflammation, without causing skin pigmentation. However, research indicates it may also influence immune modulation. It plays a role in the healing process by targeting the inflammatory, proliferative, and remodeling phases, binding to melanocortin 1 receptors. Additionally, studies show it has anti-microbial properties, inhibiting Candida albicans and Staphylococcus aureus, making it effective in preventing infections in severe wounds like burns, unlike other anti-inflammatory medications that may weaken the immune response [5].
Skin Health: With its anti-inflammatory, immune-boosting, antimicrobial, and antifungal properties, it makes it effective for treating inflammatory skin conditions [6]. Studies show its ability to reduce skin inflammation, treat contact dermatitis and eczema, suppress antigen-induced immune responses, and regulate interleukin-10 production to prevent skin irritation. Research also highlights its role in suppressing pro-inflammatory molecules like ICAM-1, further supporting its potential in improving skin health [7].
Immune Function: Alpha-MSH peptides, particularly the C-terminal tripeptide KPV, show significant therapeutic potential. It has been found to enhance antimicrobial activity, reduce fever by targeting the hypothalamus and lowering pyrogens, and boost regulatory T cells. Studies highlight its effectiveness in reducing inflammation in conditions like arthritis, autoimmune eye diseases, and acute pancreatitis. Both central and peripheral KPV administration have demonstrated fever-reducing effects in animal models [8].
Scar Formation: Studies have shown it to reduce chronic inflammation, which can lead to hypertrophic scars, such as keloids. These scars are caused by factors like widespread macrophage infiltration, TNF activity, and an abundance of neutrophils. Using alpha-MSH in this context results in smaller scars and a milder inflammatory response. This suggests that it could help prevent scarring caused by certain chemotherapy drugs. By reducing these side effects, it may also allow for higher doses of these treatments to be used, leading to better outcomes. KPV and similar peptides may soon play a pivotal role in advancing wound healing and minimizing scars after surgery [9].
Nerve Damage: As a tripeptide of α-MSH, it shows potential for protecting and regenerating nerve health. Research highlights its ability to promote nerve regeneration, stimulate axon growth, and protect against neurotoxicity, apoptosis, and DNA damage. Studies in neonatal rats, spinal cord injury models, and cultured brain cells demonstrate its protective effects, including anti-scarring properties and improved nerve repair and function after injury [10].
Stroke: KPV and α-MSH share similar therapeutic properties and show promise as treatment options for stroke [11]. Research indicates that α-MSH can aid stroke recovery by improving outcomes when administered before or during ischemia. It helps prevent further artery inflammation, reduces pro-inflammatory cytokines in the brain, and minimizes infarct size. Additionally, α-MSH may protect against stroke-related heart and kidney complications [12].
Neuroprotective properties: Studies show promise for treating neurological conditions due to its anti-inflammatory and antioxidant effects. This helps prevent neural damage caused by oxidative stress and inflammation, key drivers of neurodegeneration. Research indicates that it can reduce neural apoptosis, support cell survival, and preserve brain function. It may also slow the progression of neuroinflammatory diseases like multiple sclerosis by suppressing pro-inflammatory cytokines and protecting myelin. These qualities make it a potential peptide therapy for improving neurological health and preventing damage from neurodegenerative disorders [13].
Buy KPV Peptide for research use online today!
Buy KPV Peptide Nasal Stack With BPC-157
Buy KPV peptide nasal stack with BPC-157, available in two 15 ml or two 30 ml bottles, offering a convenient delivery method for research. This combination lets researchers study the complementary effects of KPV and BPC-157, known for their anti-inflammatory, healing, and regenerative properties.
The nasal spray format is easy to use, ensures precise application, and allows for rapid absorption, making it ideal for exploring the peptides’ combined benefits.
Buy KPV Peptide Pre-Mixed Pen
Buy KPV peptide pre-mixed peptide 2 mg pen, a convenient, ready-to-use solution for research, eliminating the need for manual mixing. Designed for accuracy and portability, it simplifies dosing and ensures consistent, reliable administration. Ideal for exploring it’s anti-inflammatory, antioxidant, and neuroprotective effects.
Pre-Mixed Cartridge Kits include a cartridge (premixed with your chosen peptide and Bacteriostatic Water), a peptide pen, carry case, and needle tips. Single mixed cartridges (available in packs of 1, 2, or 3) come with needle tips but no kit. Save 10% on a pack of 3 cartridges!
Frequently Asked Questions (FAQs) about KPV
How is KPV commonly used in research?
It is used in research to investigate its potential in reducing inflammation, promoting wound healing, and modulating immune responses. Common research applications include studies on skin conditions, gut health, and chronic inflammatory disorders.
Is KPV safe to use in research?
Direct Peptides ensures that all KPV peptides are of 99% purity and are manufactured to the highest quality standards. This makes them safe, reliable, and precise for research applications. However, it is intended strictly for research use and not for human consumption.
Are there any side effects?
Potential adverse effects could include mild irritation at the application site or unexpected interactions in specific experimental conditions. Researchers are advised to carefully follow established protocols and seek professional medical advice from a qualified health care provider. It is important to note that these peptides are strictly for research purposes and not for therapeutic use.
What forms of KPV are available?
Direct Peptides offers various formulations including 2 mg vials, nasal sprays in 15ml and 30ml bottles, pre-mixed peptide pens, and stacks for combined research purposes. These diverse options cater to a wide range of experimental requirements.
How should KPV be stored?
To maintain stability and potency, it should be stored in a cool, dry place and protected from direct sunlight. For extended storage, it is advisable to refrigerate the peptide as per the product instructions.
Can KPV be combined with other peptides?
Yes, it is often studied in combination with other peptides like BPC-157 due to their complementary effects. Research on these combinations is focused on enhancing healing and anti-inflammatory responses.
Is KPV legal?
It is legal for research purposes and is widely used in laboratory settings across various scientific fields. However, it has not been approved by regulatory bodies such as the FDA for use in humans or for medical treatments. It is essential to ensure that its use complies with local laws and guidelines related to research substances in your area. KPV remains strictly intended for research purposes only and should not be used for any off-label or unauthorised applications.
Buy KPV Peptide 2mg Vial from Direct Peptides. The lyophilized powder requires reconstitution with bacteriostatic water before it can be used in the laboratory.
Summary of Research Applications
- Potential treatment of inflammatory bowel disease.
- Potential treatment of other disease conditions in the intestine such as Chrohn’s or Colitis.
- Antimicrobial properties.
- Anti-fungal properties.
- Treatment of skin conditions.
- Reduction of scarring post surgery.
- Neuroprotection effects.
KPV Peptide Quality Assured
Direct Peptides offers 99% pure KPV peptides made to strict quality standards for research purposes. Our peptides are safe, reliable, and precise, giving researchers products they can trust.
These peptides support research on inflammation and immune response, helping to advance medical studies and improve patient care. Buy KPV peptide from Direct Peptides today.
References For Further Reading
[1] Gualtiero Colombo, Stefano Gatti, Andrea Sordi, Flavia Turcatti, et al (2007) Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury – Shock, 2007 Mar, Volume 27 (Issue 3), Pages 326-33.
[2] Guillaume Dalmasso, Laetitia Charrier-Hisamuddin, Hang Thi Thu Nguyen, et al (2007) PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation – Gastroenterology, 2007 Oct 17, Volume 134 (Issue 1), Pages 166–178.
[3] Bo Xiao, Zhigang Xu, Emilie Viennois, Yuchen Zhang, et al (2017) Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis – Molecular Therapy, 2017 Jul 5, Volume 25 (Issue 7), Pages 1628-1640.
[4] Klaus Kannengiesser, Christian Maaser, Jan Heidemann, et al (2008) Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease – Inflammatory Bowel Diseases, Volume 14, Issue 3, 1 March 2008, Pages 324–331.
[5] Mariagrazia Cutuli, Silvia Cristiani, James M Lipton, and Anna Catania (2000) Antimicrobial effects of α-MSH peptides – Journal of Leukocyte Biology, Volume 67, Issue 2, February 2000, Pages 233–239.
[6] Marcelo F. Masman, Ana M. Rodrı´guez, Laura Svetaz, et al (2006) Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties – Bioorganic & Medicinal Chemistry, Volume 14, Issue 22, 15 November 2006, Pages 7604-7614.
[7] Kênia Soares de Souza, Thiago Anselmo Cantaruti, Geraldo Magela Azevedo Jr, et al (2015) Improved cutaneous wound healing after intraperitoneal injection of alpha-melanocyte-stimulating hormone – Experimental Dermatology, 2015 Mar, Volume 24 (Issue 3), Pages 198-203.
[8] Thomas Brzoska, Thomas A Luger, Christian Maaser, Christoph Abels, and Markus Böhm (2008) Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases – Endocrine Reviews, 2008 Aug, Volume 29 (Issue 5), Pages 581-602.
[9] Caterina Lonati, Andrea Carlin, Patrizia Leonardi, et al (2013) Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats – Peptides, 2013 Dec, Volume 50, Pages 145-52.
[10] Hari Shanker Sharma (2005) Neuroprotective effects of neurotrophins and melanocortins in spinal cord injury: an experimental study in the rat using pharmacological and morphological approaches – Annals of the New York Academy of Sciences, 2005 Aug, Volume 1053, Pages 407-21.
[11] Daniela Giuliani, Sheila Leone, Chiara Mioni, Carla Bazzani, et al (2006) Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils – European Journal of Pharmacology, 2006 May 24, Volume 538 (Issue 1-3), Pages 48-56.
[12] Gualtiero Colombo, Stefano Gatti, Flavia Turcatti, Andrea Sordi, et al (2005) Gene expression profiling reveals multiple protective influences of the peptide alpha-melanocyte-stimulating hormone in experimental heart transplantation – Journal of Immunology, 2005 Sep 1, Volume 175 (Issue 5), Pages 3391-401.
[13] Eva-Verena Schaible, Arne Steinsträßer, Antje Jahn-Eimermacher, et al (2013) Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice – PLoS One, 2013 Aug 5, Volume 8 (Issue 8), Page e71056.
Why Choose Direct Peptides ?
Buy KPV peptide today from Direct Peptides, your trusted source for premium peptides. We offer a range of formulations, including 2 mg vials, peptide stacks, nasal sprays in 15ml and 30ml bottles, and pre-mixed peptide pens. Designed for diverse research needs, researchers can easily access the exact formulations they require.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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