Growth Differentiation Factor 8 (GDF-8), commonly known as Myostatin, is a crucial peptide in the Transforming Growth Factor-beta (TGF-β) superfamily. Research has shown it plays a pivotal role in regulating skeletal muscle mass, primarily acting as a negative regulator of muscle growth by inhibiting myogenesis, the formation process of muscular tissue.
Research suggests the GDF-8 peptide’s function is particularly interesting when interacting with its endogenous inhibitor, Follistatin, which binds to GDF-8 and neutralizes its activity. This interaction has significant implications for potential therapeutic applications of GDF-8 peptides.
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[1] https://pubmed.ncbi.nlm.nih.gov/18425412/
[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3738019/
[3] https://pubmed.ncbi.nlm.nih.gov/24081623/
[4] https://www.sciencedirect.com/science/ article/abs/pii/S0006291X02965009
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