Buy HGH Fragment 176-191 Peptide
Buy HGH Fragment 176-191 , a synthetic peptide derived from human growth hormone. It is often used in studies for its potential benefits in promoting fat reduction, improving body composition, and supporting weight management without the adverse side effects associated with full-length growth hormone.
Shop our Full Range of HGH Fragment 176-191 Peptides
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NEWHGH Frag 176-191 Ipamorelin CJC No DAC
£72.60 – £81.58 This product has multiple variants. The options may be chosen on the product page -
HGH Frag 176-191 Ipamorelin CJC-1295 DAC
£73.80 – £82.78 This product has multiple variants. The options may be chosen on the product page -
HGH Fragment 176-191 CJC-1295 No DAC Spray
£29.08 – £53.16 This product has multiple variants. The options may be chosen on the product page -
HGH Fragment 176-191 CJC-1295 no DAC
£21.08 – £30.06 This product has multiple variants. The options may be chosen on the product page -
HGH Fragment & CJC-1295 Dac Nasal Spray
£29.08 – £53.16 This product has multiple variants. The options may be chosen on the product page -
HGH Fragment 176-191 Nasal Spray
£25.74 – £46.48 This product has multiple variants. The options may be chosen on the product page -
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HGH Fragment CJC-1295 Dac Pre Mixed 2.5mg
£21.08 – £63.88 This product has multiple variants. The options may be chosen on the product page -
HGH Fragment & CJC-1295 Dac 2.5mg
£21.08 – £30.06 This product has multiple variants. The options may be chosen on the product page -
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HGH Frag 176-191 5mg Pre Mixed
£41.29 – £111.43 This product has multiple variants. The options may be chosen on the product page -
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HGH Fragment 176-191
£15.93 – £71.50 This product has multiple variants. The options may be chosen on the product page
What Is HGH Fragment 176-191?
HGH Fragment 176-191 is a modified section of human growth hormone (hGH) designed to focus on fat-burning properties. Specifically, it is a peptide that includes only a small portion of the hGH amino acid chain—amino acids 176 to 191.
This fragment works by mimicking the way natural human GH regulates fat metabolism, making it effective in targeting fat cells while avoiding interactions with insulin or other non-fat-related processes.
Researchers are exploring this peptide for its potential to help reduce body fat, improve body composition, and support studies in weight management. Its targeted nature makes it a subject of interest for laboratory research and healthcare investigations.
HGH Fragment 176-191 Mechanism Of Action
HGH Fragment 176-191 focuses on breaking down fat in adipose tissue. It also preserves lean muscle and avoids disruptions to blood sugar regulation. It works by stimulating lipolysis (breaking down stored fat) and preventing lipogenesis (the creation of new fat). This peptide targets beta-3 adrenergic receptors in fat cells. This prompts them to release stored triglycerides as free fatty acids, which the body can then use for energy.
Unlike full-length human growth hormone, Fragment 176-191 does not increase insulin-like growth factor 1 (IGF-1) production or interact with insulin receptors, lowering the risk of side effects often linked to hGH. Researchers have also highlighted its ability to target fat loss without affecting protein metabolism, making it a promising focus for studies on obesity, weight management, and related metabolic issues.
Structure of HGH Fragment 176-191
Sequence: H-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-Tyr-OH
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
PubChem CID: 16131447
What Are The Research Benefits of HGH Fragment 176-191
Weight Loss and Fat Burning
Fragment 176-191, known as the “lipolytic fragment,” has shown significant fat-burning and weight-loss effects in studies on mice [1]. These effects are linked to increased beta-3 adrenergic receptor (ADRB3) activity [2], which promotes fat burning in adipose tissue and thermogenesis in skeletal muscle [3]. A study by Frank NG M.D. from Monash University, Australia discovered obese mice experienced nearly 50% less weight gain after using the fragment. In comparison lean mice maintained their normal weight, suggesting regulatory pathways prevent further weight loss when body weight is ideal [4]. These findings highlight potential avenues for further research into energy regulation and weight management.
Safety Studies
Human growth hormone derivatives have raised concerns over risks such as insulin resistance, diabetes, acromegaly, cancer, hypertension, and edema [5]. However, a 2013 meta-analysis found no significant negative effects linked to to the peptide when tested in randomized, double-blind, placebo-controlled studies, whether given intravenously or orally [6].
The study showed no changes in physical exams, lab results, glucose levels, glucose tolerance, insulin sensitivity, IGF-1 levels, or adverse event rates.
It may offer the benefits of hGH without the associated risks, making it a potentially safer option for therapeutic use.
Blood Sugar Regulation
{name] Research on animals has shown that the C-terminal end of human growth hormone plays a key role in its ability to lower blood sugar levels [7]. Research on multiple fragments of this specific hGH section has identified fragment 176-191 as the most effective synthetic derivative for lowering blood sugar levels. This hypoglycemic effect is linked to a prolonged elevation in plasma insulin levels. There is growing interest in exploring it as a potential treatment for prediabetes and type 2 diabetes [8].
Supports Cartilage Repair
It may enhance the effects of hyaluronic acid (HA) injections in encouraging cartilage regeneration. Studies conducted on rabbits have shown that weekly injections of the peptide significantly increase markers of cartilage growth [9].
Furthermore, co-administration of Fragment 176-191 with HA has been observed to produce more substantial outcomes compared to using either treatment independently. This peptide, whether used alone or in conjunction with HA, shows potential in reducing disability associated with osteoarthritis. Such findings could pave the way for advanced therapies for osteoarthritis and possibly minimise the need for surgical intervention.
Enhancing Breast Cancer Chemotherapy
Recent research has explored improving breast cancer chemotherapy using Chitosan nanoparticles loaded with both doxorubicin and an human GH fragment (176–191 peptide). Studies showed that the peptide fragment increases doxorubicin’s binding to breast cancer proteins, boosting its anticancer effects in MCF-7 cells. Nanoparticles carrying both doxorubicin and the human GH fragment were more effective and performed better than those carrying only doxorubicin. This approach offers a promising way to make chemotherapy more effective while reducing side effects [10].
Buy HGH Fragment 176-191 Peptidel Vial for research online today! Available as lyophilised powder in 2 mg, 5 mg, and 10 mg vials. Available as a kit which includes syringes and bacteriostatic water for reconstituting the lyophilised powder.
Buy HGH Fragment 176-191 6 mg, Ipamorelin 3 mg, CJC-1295 no DAC 3 mg Triple Blend
Buy HGH Fragment 176-191, Ipamorelin, and CJC-1295 no DAC Triple Blend. The 12 mg vial combines three peptides studied for their potential benefits in fat metabolism, lean body mass, recovery, and natural growth hormone production. It also supports protein synthesis and muscle preservation.
It promotes fat burning, Ipamorelin stimulates growth hormone release without excessive side effects, and CJC-1295 enhances the body’s natural hormone production. These peptides are experimental and intended strictly for research purposes.
Buy HGH Fragment 176-191 Nasal Spray
Buy HGH Fragment 176-191 nasal spray , a research peptide designed for easy administration. It targets fat metabolism by focusing on a specific portion of the human GH molecule, aiming to promote fat burning and regulate body composition with fewer side effects than full-length human Growth Hormone.
It is for research purposes only and not approved for medical use. Available in 15 ml and 30 ml glass spray bottles, buy HGH Fragment 176-191 nasal spray here.
Frequently Asked Questions (FAQs) about HGH Fragment 176-191
Is HGH Frag 176-191 safe?
Human growth hormone (hGH) derivatives have raised concerns over risks such as insulin resistance, diabetes, acromegaly, cancer, hypertension, and edema. However, a 2013 meta-analysis found no significant side effects linked to fragment 176-191 when tested in randomized, double-blind, placebo-controlled studies, whether given intravenously or orally.
The study showed no changes in physical exams, lab results, glucose levels, glucose tolerance, insulin sensitivity, IGF-1 levels, or adverse event rates.
Frag 176-191 may offer the benefits of hGH without the associated risks, making it a potentially safer option for therapeutic use.
What is the difference between Fragment 176-191 and HGH 191AA?
HGH 191AA is the full-length human growth hormone with 191 amino acids, promoting growth, tissue repair, and metabolism regulation. In contrast, Frag 176-191 is a modified peptide focusing solely on fat metabolism, enhancing fat loss without growth effects. While HGH 191AA has broad systemic benefits, the fragment offers a targeted approach to weight management with fewer side effects. Visit the HGH191aa for more information.
Is Fragment 176-191 legal?
The legality varies by country and its intended use. It is not approved by the FDA for general use, and its application is often restricted to laboratory research use. It is important to check local regulations and ensure compliance before obtaining or using such peptides.
Are HGH Frag 176-191 and AOD-9604 the same peptide?
HGH Frag 176-191 and AOD-9604 are peptides studied for fat loss and metabolism. Fragment 176-191, a segment of human growth hormone, targets fat tissue to promote breakdown and prevent storage without affecting insulin or IGF-1 levels. AOD-9604 is a modified version of this fragment, enhanced for obesity research with improved stability and effectiveness. It mimics the fat-burning properties of HGH while being backed by distinct safety studies for therapeutic use. Both peptides differ in structure, mechanism, and applications. AOD-9604 is also available to buy from Direct Peptides.
Are there any side effects of Fragment 176-191?
While it is designed to minimise side effects, some studies have reported mild reactions such as redness or irritation at the injection site. It is important to remember it is not a dietary supplement and it is recommended to consult with a healthcare provider before starting any studies.
Buy HGH Fragment 176-191 from Direct Peptides, global supplier of premium research products.
Summary of Research Applications
- Enhances fat burning
- Improves metabolic efficiency
- Increases energy levels
- Aids in weight management
- Supports glucose control
- Reduces diabetes risk factors
- Potential treatment for osteoarthritis
- Promotes cartilage regeneration and tissue repair
Buy HGH Fragment 176-191 Pre-Mixed 5mg Pen from Direct Peptides. Pre-Mixed Cartridge Kits include a peptide cartridge, pen, carry case, and needle tips. Single cartridges (1, 2, or 3) come with needle tips but not a full kit. Save 10% when you buy 3 cartridges.
HGH Fragment 176-191 Peptide Quality Assured
Direct Peptides offers high-quality HGH Fragment 176-191 with 99% purity, meeting strict research standards. Our peptides are produced with precision to ensure reliable and consistent results in scientific studies.
These peptides are commonly used in research related to fat metabolism, cell regeneration, and overall health. With Direct Peptides, researchers can rely on a product designed to support advancements in medical science. Buy HGH Fragment 176-191 from Direct Peptides today!
View the High Performance Liquid Chromatography – HPLC Certificate here.
References For Further Reading
[1] M Heffernan, R J Summers, A Thorburn, E Ogru, et al (2001) The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice – Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9.
[2] Raquel Ferrer-Lorente, Cristina Cabot, José-Antonio Fernández-López, and Marià Alemany (2005) Combined effects of oleoyl-estrone and a beta3-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats – Life Sciences, 2005 Sep 2, Volume 77 (Issue 16), Pages 2051-8.
[3] M A Heffernan, W J Jiang, A W Thorburn, and F M Ng (2000) Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism – American Journal of Physiology, Endocrinology & Metabolism, 2000 Sep, Volume 279 (Issue 3), Pages E501-7.
[4] F M Ng, J Sun, L Sharma, R Libinaka, W J Jiang, and R Gianello (2000) Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone – Hormone Research, 2000, Volume 53 (Issue 6), Pages 274-8.
[5] M A Heffernan, A W Thorburn, B Fam, R Summers, et al (2001) Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment – International Journal of Obesity and Related Metabolic Disorders, 2001 Oct, Volume 25 (Issue 10), Pages 1442-9.
[6] Heike Stier, Evert Vos, and David Kenley (2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans – Journal of Endocrinology & Metabolism, 2013, Volume 3 (Issue 1-2), Pages 7-15.
[7] F M Ng and J Bornstein (1978) Hyperglycemic action of synthetic C-terminal fragments of human growth hormone – American Journal if Physiology, 1978 May, Volume 234 (Issue 5), Pages E521-6.
[8] Jesús Devesa, Cristina Almengló, and Pablo Devesa (2016) Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth? – Clinical Medicine Insights: Endocrinology and Diabetes, 2016 Oct 12, Volume 9, Pages 47–71.
[9] Dong Rak Kwon and Gi Young Park (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model – Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32.
[10] Mahmoud M Habibullah, Syam Mohan, Nabeel Kashan Syed, Hafiz A Makeen, et al (2022) Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells – Drug Design, Development & Therapy, 2022 Jun 27, Volume 16, Pages 1963–1974.
Why Choose Direct Peptides ?
Buy HGH Fragment 176-191 with Direct Peptides , your trusted source for 99% pure premium peptides. We offer a wide range of formulations to meet various research needs, including peptide vials (2mg, 5mg, 10mg), peptide blends and stacks, nasal sprays (15ml, 30ml), and pre-mixed peptide pens. We’re dedicated to providing precise formulations to support your projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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