What is PT-141?

What is PT-141? – Direct Peptides

PT-141 is a synthetic peptide also known as Bremelanotide, developed from Melanotan ii (MT-2). It’s a generic term referring to the new pharmaceutical-grade synthetic aphrodisiac peptide. PT-141 has created a potential resolution to the issue of erectile dysfunction or impotence in men and the sexual arousal disorder in women with very few adverse effects, but is still classed as a research peptide [1].

There is a significant percentage of both men and women suffering from sexual dysfunction. This peptide designed by scientists is a synthetic aphrodisiac peptide developed to help these men and women by increasing sexual desire and overall sex drive. There is a significant difference between PT141 and Viagra as well as other medications with similar benefits.

Viagra often available with doctor’s prescription, is currently approved by the FDA, and is popular in the male population. Viagra works by increasing the blood flow to enhance the male penile erections. Viagra can have adverse side effects especially to those suffering with high blood pressure leading to further medical problems due to its effects on the cardiovascular system.

PT-141, however, works directly to the hypothalamus to increase your sexual desire increasing the potential benefits to both the male and female population. For that reason, Viagra, Levitra, and other medications are not precisely an aphrodisiac since they don’t directly affect the libido.

Treatment using PT-141 and PDE5 inhibitors do have a synergistic effect when treating low libido. While initially tested during clinical studies as a sunless tanning agent, it showed unexpected side effects of spontaneous erections and sexual arousal [2].

In clinical trials of PT-141 peptide therapy, it proved useful in treating erectile dysfunction both in male and in the female by increasing their sex drive. PT 141 peptide is a cyclic heptapeptide lactam analogue of alpha-MSH, which activates the central nervous system’s the melanocortin receptors MC3-R and MC4-R.

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PT-141 Peptide for Treating Sexual Dysfunction:

During scientific testing following the administration of PT141 peptide subjects reported to feel the effects of the peptide and increase in sexual desire within a couple of hours. Compared to some other marketed aphrodisiacs, PT-141 provides lasting effects that can last for six to seventy-two hours.

What are the Side Effects of PT-141?

Pt-141 does make you feel not only good but also sexually aroused. According to an anonymous patient suffering from sexual dysfunction in a clinical trial, taking it will make you feel more energetic. It increases libido, making you have the urge and to be in the mood, with very few side effects. One known side effect of any peptide is slight itching in the injection site if administering subcutaneously.

PT 141 peptide directly effects the brain instead of acting on the circulatory system like with Viagra. Clinical trials using nasal sprays have demonstrated it’s effectiveness in increasing sexual desire [2]. From the brain, it goes on to switch the neural circuit responsible for making a person feel sexually aroused.

In the future, it is hoped that with further clinical development to establish the long term safety and efficacy PT 141 peptide maybe be FDA approved for the treatment of sexual disorders including hypoactive sexual desire disorder, female sexual dysfunction, female sexual arousal disorder in premenopausal women and low sexual desire in men and women.

References:

[1] P.B.Molinoff, A.M.Shadiack, D.Earle, L.E.Diamond, and C.Y.Quon (2003) PT-141: a melanocortin agonist for the treatment of sexual dysfunction – Annals of the New York Academy of Sciences,  2003 Jun:994:96-102.