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LL-37 (Cap-18) 5mg Pre Mixed

£45.25£130.75

LL-37, also known as CAP-18, is a one-of-a-kind human peptide that belongs to the cathelicidin antimicrobial peptide family.  LL-37 has wide antimicrobial activity against a variety of pathogens, including bacteria, viruses such as HIV, fungi, and even those found in biofilms.

Pre Mixed Cartridge and Kit:

  • 
1 x Cartridge (The cartridge is premixed with the peptide vial of your choice and Bacteriostatic Water)
  • 1 x Peptide Cartridge Pen
  • 1 x Pen Carry Case
  • 3 x Pen Needle Tips

Single Mixed Cartridges (1,2 & 3) Come with:

  • 1,2 or 3 x Cartridge (The cartridge is premixed with the peptide vial of your choice and Bacteriostatic Water)
  • 3 x Pen Needle Tips

The single 1,2 & 3 cartridges do not come with a kit.

Buy 10 and get 10% Discount

606 in stock

Description

LL-37 (Cap-18) Pre Mixed Pen 5mg

This product is intended for research purposes only. To be used by trained professionals only.

LL-37, also known as CAP-18, is a human peptide that belongs to the cathelicidin antimicrobial peptide family. It modulates innate immune responses and prevents the production of bacterial biofilms in the human immune system [1].

During an immunological response, this multifunctional peptide can be up-regulated. Its skills include the ability to protect mice from deadly endotoxemia [2], indicating its potential for therapeutic uses in infections and sepsis. It has also been shown in studies to inhibit the production of bacterial biofilms, which are organised communities of bacteria that contribute to chronic infections [3].

The immunomodulatory activity of LL-37 (cap-18) pre mixed peptide has been investigated in the context of autoimmune disorders and viral infections. It has been discovered that patients with moderate-to-severe plaque psoriasis had both CD4+ and CD8+ LL-37-reactive T cells, implying that LL-37 (Cap-18) pre mixed peptide may influence the activation of these immune cells [4].

In addition to immunomodulatory effects, LL-37 (cap-18) pre mixed peptide exhibits angiogenic activities, encouraging the formation of new blood vessels via formyl peptide receptor-like 1 expressed on endothelial cells [5]. This discovery brings up new therapeutic possibilities in wound healing and tissue regeneration.

It has also been investigated how LL-37 (cap-18) pre mixed peptide interacts with lipid bilayers. Despite being highly charged, LL-37 interacts with lipid bilayers in a variety of ways depending on their composition, which may influence its antibacterial action [6].

Interestingly, research has demonstrated that the LL-37 (cap-18) pre mixed peptide can decrease HIV-1 replication, implying that it could be used in antiviral therapy. Furthermore, LL-37’s antibacterial activity has been shown to be conformation-dependent, shedding light on the structural basis of its function [7].


References:

[1] https://journals.aai.org/jimmunol/ article/191/10/4895/86783

[2] https://journals.aai.org/jimmunol/ article/169/7/3883/35412

[3] https://journals.asm.org/doi/full/ 10.1128/iai.00318-08

[4] https://www.mdpi.com/ 2076-393X/8/3/517

[5] https://www.jci.org/ articles/view/17545

[6] https://pubs.acs.org/doi/abs/ 10.1021/bi0273563

[7] https://www.jbc.org/article/ S0021-9258(18)93785-3/fulltext


Sequence: Leu Leu Gly Asp-Phe-Phe Arg Lys-Ser Lys-Glu Lys.11e-Gly Lys Glu Phe Lys-Arg Ile Val-Gln Are Ile-Lys Asp Phe Leu Arg Asn Leu Val Pro-Arg Thr-Glu-Ser

Molecular Formula: C205 H340 N60 O53

Molecular Weight: 4493.342 g/mol

Storage: Lyophilized peptides to be stored below -18°C

Research use only. Not for human or animal consumption!

LL-37 HPLC 2023 Certificates_DIRECT PEPTIDES

 

 

 

 

 

 

 

 


DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.


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