LL-37 (Cap-18) Pre Mixed Pen 5mg
This product is intended for research purposes only. To be used by trained professionals only.
LL-37, also known as CAP-18, is a human peptide that belongs to the cathelicidin antimicrobial peptide family. It modulates innate immune responses and prevents the production of bacterial biofilms in the human immune system .
During an immunological response, this multifunctional peptide can be up-regulated. Its skills include the ability to protect mice from deadly endotoxemia , indicating its potential for therapeutic uses in infections and sepsis. It has also been shown in studies to inhibit the production of bacterial biofilms, which are organised communities of bacteria that contribute to chronic infections .
The immunomodulatory activity of LL-37 (cap-18) pre mixed peptide has been investigated in the context of autoimmune disorders and viral infections. It has been discovered that patients with moderate-to-severe plaque psoriasis had both CD4+ and CD8+ LL-37-reactive T cells, implying that LL-37 (Cap-18) pre mixed peptide may influence the activation of these immune cells .
In addition to immunomodulatory effects, LL-37 (cap-18) pre mixed peptide exhibits angiogenic activities, encouraging the formation of new blood vessels via formyl peptide receptor-like 1 expressed on endothelial cells . This discovery brings up new therapeutic possibilities in wound healing and tissue regeneration.
It has also been investigated how LL-37 (cap-18) pre mixed peptide interacts with lipid bilayers. Despite being highly charged, LL-37 interacts with lipid bilayers in a variety of ways depending on their composition, which may influence its antibacterial action .
Interestingly, research has demonstrated that the LL-37 (cap-18) pre mixed peptide can decrease HIV-1 replication, implying that it could be used in antiviral therapy. Furthermore, LL-37’s antibacterial activity has been shown to be conformation-dependent, shedding light on the structural basis of its function .
 https://journals.aai.org/jimmunol/ article/191/10/4895/86783
 https://journals.aai.org/jimmunol/ article/169/7/3883/35412
 https://journals.asm.org/doi/full/ 10.1128/iai.00318-08
 https://www.mdpi.com/ 2076-393X/8/3/517
 https://www.jci.org/ articles/view/17545
 https://pubs.acs.org/doi/abs/ 10.1021/bi0273563
 https://www.jbc.org/article/ S0021-9258(18)93785-3/fulltext
Sequence: Leu Leu Gly Asp-Phe-Phe Arg Lys-Ser Lys-Glu Lys.11e-Gly Lys Glu Phe Lys-Arg Ile Val-Gln Are Ile-Lys Asp Phe Leu Arg Asn Leu Val Pro-Arg Thr-Glu-Ser
Molecular Formula: C205 H340 N60 O53
Molecular Weight: 4493.342 g/mol
Storage: Lyophilized peptides to be stored below -18°C
Research use only. Not for human or animal consumption!
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