Buy Melanotan 1 Peptide
Buy Melanotan 1, a synthetic peptide designed to stimulate melanin production in the skin, enhancing tanning while offering protective benefits against UV-induced damage. It has also shown potential in treating skin disorders, reducing the risk of heart disease, lowering inflammation and blood pressure, improving cognitive function, aiding stroke recovery, and supporting fat loss.
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Melanotan 1 Nasal Spray
£25.19 – £45.38 This product has multiple variants. The options may be chosen on the product page
What Is Melanotan 1?
Melanotan 1, also known as MT-1 or Afamelanotide, is a synthetic analogue of the naturally occurring melanocortin peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed to stimulate melanogenesis, which is the process responsible for producing melanin in the skin.
By binding to melanocortin receptors, Melanotan 1 enhances the skin’s ability to tan by increasing melanin production. This provides a targeted solution for individuals to potentially reduce UV-related skin damage. Researchers are particularly interested in investigating its applications in photoprotection, skin pigmentation disorders, and other conditions influenced by the melanocortin system.
Melanotan 1 Mechanism Of Action
Melanotan 1 works by mimicking the effects of the natural hormone alpha-melanocyte-stimulating hormone (α-MSH). This hormone binds to melanocortin receptors, particularly MC1R, which are found on melanocytes—the cells responsible for producing melanin. Upon activation of these receptors, melanotan 1 stimulates the melanocytes to enhance melanin synthesis.
Increased melanin levels in the skin lead to a darker pigmentation, which may provide a degree of protection against UV radiation. This process effectively bypasses the need for prolonged sun exposure to achieve a tanned appearance while potentially reducing the risks associated with UV-induced skin damage.
Structure of Melanotan 1
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular Formula: C78H111N21O19
Molecular Weight: 1646.8 g/mol
PubChem CID: 16197727
What Are The Research Benefits of Melanotan 1
Sunless Tanning: MT-1 has shown promising results in enhancing tanning and reducing sunburn, particularly for those with poor-tanning skin types (Fitzpatrick types I and II). Phase 1 trials reveal it increases tanning by 75%, reduces burning by 47%, and requires 50% less UV exposure compared to controls, with tans lasting three weeks longer [1]. MT-1 also benefits individuals with variant MC1 receptors, boosting melanin production and offering better UV protection, potentially lowering skin cancer risks [2].
Actinic Keratosis: Also called solar keratosis, this precancerous skin condition is caused by prolonged UV exposure and can progress to squamous cell carcinoma if untreated. Visible lesions can be removed, but many are too small to detect. Researchers are exploring the peptide as a potential treatment to target hidden lesions and prevent skin cancer [3].
Potential Treatment For Vitiligo: Vitiligo is a chronic skin condition characterised by the loss of pigmentation. Studies indicate when combined with UVB light therapy, it stimulates melanin production and melanocyte proliferation. Nearly half of patients in a small trial experienced improved pigmentation and faster repigmentation. Research suggests that combining melanotan 1 with existing vitiligo treatments enhances outcomes and may also have potential applications for hypopigmented scars [4].
Decline in Cognitive Function: Research in mice indicates that it may protect against Alzheimer’s disease by reducing amyloid beta plaques, protecting neurons, and improving cognitive function [5]. It’s action at the MC4 receptor boosts neurogenesis, enhances astrocyte function, and increases brain-derived neurotrophic factor (BDNF), which supports synapse stability. Unlike many treatments, MT-1 shows promise for improving Alzheimer’s rather than simply slowing its progression [6].
Recovering Function After a Stroke: Research shows that treatment not only improves biomarkers in Alzheimer’s disease but also reduces brain damage and enhances memory recovery after strokes, even when administered 9 hours later. MT-1 appears to activate repair mechanisms and improve synaptic plasticity by rerouting learning and memory to healthier brain areas, linked to the overexpression of the Zif268 gene [7].
Research on Neuroinflammation: Melanotan 1 activates the MC1 receptor, known for skin and hair pigmentation, but it also reduces inflammation in the central nervous system. In mouse models of multiple sclerosis, MT1 prevents myelin loss, protects neurons, and supports recovery [8].
In experimental autoimmune uveitis (EAU) , an inflammatory eye disorder, MT1 suppresses T-cell activity via the MC4 receptor, offering a potential alternative to steroids and immunosuppressants. Localized eye administration has proven effective with fewer systemic side effects [9].
Another study found that activating MC1R with BMS-470539 helps reduce early brain injury after subarachnoid hemorrhage by controlling neuroinflammation through the AMPK/TBK1/NF-κB signaling pathway. This approach limits microglial activation, encourages anti-inflammatory responses, and reduces neutrophil infiltration, showing its potential for protecting the brain [10].
Blood Pressure Research: Studies show that it can lower high blood pressure in hypertensive mice without affecting normal blood pressure. Unlike current blood pressure medications, it avoids the risk of hypotension, which can cause severe side effects, especially in the elderly. This makes it a promising candidate for future drug development [11].
Advancing Research in Cardiovascular Health: Studies in rats show that MT1 and other melanocortins can reduce heart attack injury and improve circulation. Administering MT-1 during CPR with epinephrine helps restore arterial pressure and heart rate, reverses metabolic acidosis, lowers inflammation, and boosts gene expression linked to cardiac function. Survival rates improved by 81%, suggesting MT1 or similar melanocortins could become key in advanced cardiac life support [12].
Fat Loss Studies: It interacts with melanocortin receptors, including MC5R, to enhance fatty acid oxidation in muscles and shift fat cells from storage to burning. Studies in mice suggest its fat-burning effects are complex, involving multiple receptors and pathways. It holds potential for research into altering fatty acid metabolism and could benefit individuals unable to exercise due to obesity, disability, or injury [13].
Buy Melanotan 1 for research online today!
Melanotan 1 Peptide Quality Assured
At Direct Peptides , we provide 99% pure Melanotan peptides, made to strict quality standards for research. Buy Melanotan 1 from us today, we ensure safety, reliability, and precision.
Buy Melanotan 1 peptide, a synthetic version of alpha-melanocyte-stimulating hormone. It is being studied for potential benefits in treating skin disorders like vitiligo and erythropoietic protoporphyria. Research also suggests it may improve lipid profiles, reduce oxidative stress, and lower inflammation, helping prevent chronic conditions like arthritis and diabetes.
Summary of Research Applications
- Treats a number of skin disorders
- Reduces the risk of heart disease
- Reduces inflammation
- Helps reduce blood pressure
- Enhances cognitive performance
- Supports recovery after a stroke
- Supports fat reduction
Buy Melanotan 1 Peptide Nasal Spray
Buy Melanotan 1 nasal spray , available in 15 ml and 30 ml spray bottles. It offers a non-invasive alternative to injections, delivering peptides through the nasal passages for quick absorption.
It’s seen as a convenient option for research use, such as enhancing pigmentation. Further research is needed to confirm its efficacy, consistency, and long-term safety compared to injections.
Frequently Asked Questions (FAQs) about Melanotan 1
What is Melanotan 1?
It is a synthetic peptide that mimics the action of the alpha-melanocyte-stimulating hormone (α-MSH) in the body. It is primarily being researched for its ability to stimulate melanin production, which gives the skin a tanned appearance.
How is Melanotan 1 used?
It is intended for research purposes only. It is not approved for cosmetic use or self-administration. Researchers often utilise it in studies exploring its effects on skin pigmentation and certain medical conditions like vitiligo.
What are the potential benefits of Melanotan 1?
Research suggests that it may reduce UV radiation exposure by promoting skin pigmentation, potentially minimising the risks associated with prolonged sun exposure. It is also being studied for possible therapeutic applications in skin disorders and other health conditions like inflammation and oxidative stress.
Is Melanotan 1 safe?
It should only be handled by qualified researchers in a controlled environment. It is essential to follow all safety guidelines due to its experimental status. Always purchase from reputable suppliers to ensure high quality and purity.
Where can I buy Melanotan 1?
Direct Peptides is a trusted provider of 99% pure Melanotan peptides. Our products are manufactured to strict quality standards, ensuring safety, reliability, and precision for research purposes. Buy Melanotan 1 from us with confidence for all your research needs.
Is Melanotan 1 legal?
The legal status varies depending on the country and its regulations. In the United States, it has not been approved by the Food and Drug Administration (FDA) for medical use, meaning it cannot be legally marketed as a drug or treatment. However, it can be sold for research purposes only. It is crucial to ensure that any purchase complies with local laws and is strictly intended for use by qualified professionals in scientific research.
Buy Melanotan 1 for scientific research use from Direct Peptides online.
References For Further Reading
[1] Robert T Dorr, Gregory Ertl, Norman Levine, Chris Brooks, et al (2004) Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers – Archives of Dermatology, 2004 Jul, Volume 140 (Issue 7), Pages 827-35.
[2] Liesel M Fitzgerald, Jayne L Fryer, Terence Dwyer, and Stuart M Humphrey (2006) Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles – Peptides, Volume 27, Issue 2, February 2006, Pages 388-394.
[3] C. Ferrándiz‐Pulido, M. T. Fernández‐Figueras, and A. Quer, C. Ferrándiz (2011) An eruptive pigmented lesion after melanotan injection – Clinical and Experimental Dermatology, Volume 36, Issue 7, 1 October 2011, Pages 801–802.
[4] Henry W Lim, Pearl E Grimes, Oma Agbai, Iltefat Hamzavi, et al (2015) Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial – JAMA Dermatology, 2015 Jan, Volume 151 (Issue 1), Pages 42-50.
[5] Daniela Giuliani, Maria Galantucci, Laura Neri, Fabrizio Canalini, et al (2014) Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease – European Journal of Pharmacology, 2014 Oct 5, Volume 740, Pages 144-50.
[6] Eleonora Daini, Eleonora Vandini, Martina Bodria, Wenjie Liao, et al (2023) Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice – Front Immunology, 2023 Jan 10, Volume 13, Page 1082036.
[7] Daniela Giuliani, Alessandra Ottani, Letteria Minutoli, Vincenzo Di Stefano, et al (2009) Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268 – Brain, Behaviour & Immunity, 2009 Aug, Volume 23 (Issue 6), Pages 844-50.
[8] Nadine Mykicki, Alexander M Herrmann, Nicholas Schwab, René Deenen, et al (2016) Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease – Science Translational Medicine, 2016 Oct 26, Volume 8 (Issue 362), Page 362ra146.
[9] Andrea E Edling, Danilo Gomes, Timothy Weeden, John Dzuris, et al (2011) Immunosuppressive activity of a novel peptide analog of α-melanocyte stimulating hormone (α-MSH) in experimental autoimmune uveitis – Journal of Neuroimmunology, 2011 Jul, Volume 236 (Issues 1-2), Pages 1-9.
[10] Weilin Xu, Jun Mo, Umut Ocak, Zachary D Travis, et al (2019) Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats – Neurotherapeutics, 2019 Aug 29, Volume 17 (Issue 1), Pages 294–308.
[11] Petteri Rinne, Anna-Maija Penttinen, Wendy Nordlund, Markku Ahotupa, and Eriika Savontaus (2013) α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice – PLoS One, 2013 Aug 16, Volume 8 (Issue 8), Page e72857.
[12] Alessandra Ottani, Laura Neri, Fabrizio Canalini, Anita Calevro, et al (2014) Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest – European Journal of Pharmacology, 2014 Dec 15, Volume 745, Pages 108-16.
[13] Juan Ji An, Yumie Rhee, Se Hwa Kim, Dol Mi Kim, et al (2007) Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle – Journal of Biological Chemistry, 2007 Feb 2, Volume 282 (Issue 5), Pages 2862-70.
Why Choose Direct Peptides ?
Buy Melanotan 1 today from Direct Peptides, your trusted source for high-quality peptides. We cater to a wide range of research needs, ensuring researchers have access to the exact formulations they need for their projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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