Buy Hexarelin Peptide
Buy Hexarelin, a synthetic growth hormone secretagogue, that has shown potential benefits in improving cardiac function, reducing oxidative stress, and promoting muscle mass preservation, making it a promising compound for addressing conditions like heart failure and muscle wasting.
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Hexarelin CJC-1295 DAC Peptide Stack
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Hexarelin CJC-1295 NO DAC Peptide Stack
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Hexarelin 2mg Pre Mixed
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Hexarelin Nasal Spray
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Hexarelin
£14.58 – £38.15 This product has multiple variants. The options may be chosen on the product page
What Is Hexarelin?
Hexarelin, also known as Examorelin, is a synthetic peptide classified as a growth hormone secretagogue (GHS). It functions by mimicking the action of ghrelin, a natural hormone that stimulates the release of growth hormone (GH) from the pituitary gland.
Structurally, hexarelin is a hexapeptide composed of six amino acids. It is designed to strongly stimulate GH release. Unlike natural ghrelin, it resists enzymatic breakdown, making it more stable and effective in the body.
Studies have shown it to be beneficial in improving muscle strength, supporting heart function, and reducing issues like oxidative stress. Its ability to protect muscles and heart cells also makes it valuable for treating conditions such as heart failure and muscle loss. Hexarelin is still being studied to better understand how it works and how it can be safely used.
Hexarelin Mechanism Of Action
The primary mechanism of hexarelin revolves around its binding to the growth hormone secretagogue receptor (GHS-R), which is also referred to as the ghrelin receptor. This interaction stimulates the secretion of GH. In turn this triggers downstream effects such as enhanced protein synthesis, increased lipolysis, and improved cellular regeneration.
Furthermore, hexarelin has been shown to exhibit cardioprotective properties, including reducing oxidative stress and improving cardiac function, which has made it a subject of interest in treating heart-related conditions.
Notably, research has indicated that hexarelin not only influences GH release but also impacts other systems in the body, such as the regulation of glucose and lipid metabolism, as well as anti-inflammatory effects.
While promising, the clinical application of hexarelin requires further investigation to fully understand its long-term effects and potential therapeutic uses. Its ability to target multiple pathways makes it a valuable molecule for studies addressing metabolic disorders, muscle wasting, and cardiovascular health.
Structure of Hexarelin
Sequence: H-His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula: 47H58N12O6
Molecular Weight: 887.0 g/mol
PubChem CID: 6918297
What Are The Research Benefits of Hexarelin
Promotes GH Secretion
A clinical study has shown that it helps trigger GH in idiopathic Growth Hormone Deficiency (GHD) patients and short normal children, outperforming GHRH. However, it shows minimal effect in cases of GHD caused by anatomical abnormalities, except in one instance with a pituitary cyst. The study confirms Hex works via the hypothalamus but is ineffective in hypothalamic-pituitary disconnection [1].
Enhances Lipolysis
Hexarelin stimulates GH secretion, which helps break down fat (lipolysis) and supports better body composition and energy regulation. One study explored hexarelin’s potential to reduce atherosclerosis in rats, a condition where fatty deposits, cholesterol, calcium, and other substances build up in the arteries, forming plaques. The results showed that it may help treat atherosclerosis by reducing plaque formation, improving cholesterol levels, increasing nitric oxide, and limiting calcium buildup and cell growth [2].
Supports Cardiovascular Health
It has shown promising effects in protecting the heart by reducing oxidative stress and inflammation while promoting heart health. It has been effective in improving how the left ventricle functions and in lowering cardiac fibrosis in animal studies [3].
It enhances heart performance through specific receptors, with studies showing it can boost heart pumping ability (LVEF) without impacting blood pressure or heart rate [3]. Research also suggests it may protect against abdominal aortic aneurysms (AAA) by strengthening the aortic structure, reducing inflammation, and safeguarding heart cells from damage [4].
Another study explored how it protects heart cells (cardiomyocytes) from damage caused by angiotensin II, a factor in heart failure. In rat heart cells, hexarelin reduced heart cell death, improved survival, and affected proteins linked to cell health. It also increased GHS-R expression, suggesting a potential protective mechanism [5].
Further research is needed to validate these benefits.
Improves Cellular Regeneration
Research suggests it may help with tissue repair and regeneration. One study found it could support brain cell growth in mice after radiation damage [6], while another showed it improved heart function by reducing inflammation and fibrosis in heart injury models [7]. These findings indicate hexarelin could help with recovery from injuries and prevent heart damage after a heart attack.
Modulates Immune Response
The peptide reduces inflammation by lowering pro-inflammatory cytokines and improving immune regulation. One study tested its potential to treat acute respiratory distress syndrome (ARDS) in mice. Hexarelin, known for its anti-inflammatory and heart-protective effects, was given before or after ARDS was induced. Treated mice showed better lung function, fewer immune cells and neutrophils in the lungs, and less lung scarring. These results suggest hexarelin may help reduce inflammation and prevent lung damage in ARDS [8].
Potential Metabolic Benefits
The peptide may aid metabolic health by enhancing glucose metabolism and improving insulin sensitivity, which are secondary effects of its GH-dependent actions. One study investigated the effects of hexarelin on glucose metabolism in rats with type 2 diabetes. The results showed that hexarelin improved insulin sensitivity and positively impacted blood lipid levels, suggesting its potential use as a treatment for metabolic disorders [9].
Maintains Bone Density
It has shown potential in improving bone density by stimulating the secretion of growth hormone (GH), which plays a pivotal role in bone health. Increased GH levels promote the production of insulin-like growth factor 1 (IGF-1), a key hormone that aids in bone formation and mineralisation. This effect is particularly beneficial for individuals at risk of osteoporosis or age-related bone loss, as it may strengthen skeletal integrity and reduce the chances of fractures [10].
Effects on Skeletal Muscle
It has demonstrated significant potential in promoting skeletal muscle growth and repair in studies. Its growth hormone-releasing properties can stimulate muscle protein synthesis, which is essential for muscle development and recovery. Research indicates that hexarelin may enhance muscle strength and mass, particularly in conditions of muscle wasting, sarcopenia, or cachexia. Additionally, it could improve physical performance and foster faster recovery after injury or intense physical activity, making it a promising candidate for therapies aimed at maintaining or restoring skeletal muscle health [11] [12].
Supports Sleep Regulation
Hex has been linked to improvements in sleep quality through its interactions with growth hormone secretion and hypothalamic pathways. Increased levels of GH during sleep play a critical role in deepening restorative phases, such as slow-wave sleep, which is essential for recovery and overall health. By promoting more consistent and rejuvenating sleep cycles, hexarelin may indirectly enhance cognitive function and physical performance [13].
Buy Hexarelin for research online today!
Buy Hexarelin CJC-1295 no DAC Peptide Stack
Buy Hexarelin and CJC-1295 without DAC . They are often combined in research to explore their synergistic effects on growth hormone release. Hexarelin stimulates the pituitary gland, while CJC-1295 acts as a GHRH analog, targeting different pathways in the endocrine system.
This combination may enhance growth hormone pulses, potentially having beneficial effects on cell repair, muscle growth, and fat metabolism. Further studies are needed to evaluate their efficacy, safety, and optimal dosing. Buy Hexarelin 2mg and CJC-1295 no DAC 2mg Peptide Stack for research today.
Buy Hexarelin Peptide Nasal Spray
Buy Hexarelin nasal spray , a method of administering the peptide through the nasal mucosa. This delivery route offers a non-invasive and convenient alternative to injections, making it more appealing for certain research applications.
The nasal spray allows for effective absorption of hexarelin into the bloodstream via the rich vascular network in the nasal passages. Further studies are essential to determine its bioavailability, safety, and long-term effects compared to traditional administration methods. Available in 15 ml and 30ml, you can buy Hexarelin Nasal Spray here.
Frequently Asked Questions (FAQs) about Hexarelin
Are there any side effects of hexarelin?
Like most peptides, it may cause side effects in some individuals. These can include fatigue, increased appetite, water retention, and temporary redness or discomfort at the injection site. More extensive clinical studies are required to fully understand its safety profile.
Is hexarelin approved for human use?
Currently, it is not approved for widespread human use and is typically restricted to research purposes. Although its effects have shown promise in preclinical and early-stage studies, additional clinical trials are necessary to confirm its safety and efficacy.
How is hexarelin administered?
It is usually administered via subcutaneous or intramuscular injection. The dosage and frequency depend on the intended use and research protocols, and it should only be handled under professional guidance in research settings.
Can hexarelin enhance athletic performance?
While it may support muscle growth and recovery due to its GH-stimulating properties, it is prohibited for use by athletes under the rules of major sports organizations. Administering it for this purpose is not legal or recommended.
Is hexarelin legal?
Hexarelin’s legal status varies by region. It is often classified as a research chemical, legal for investigational use but not approved for medical treatment or human consumption. The FDA has not approved it for medical use in the U.S., so it cannot be marketed or prescribed. Always check local laws before purchasing or using peptides.
What makes hexarelin unique compared to other peptides?
It is distinct for its strong growth hormone-releasing capacity and additional cardioprotective and anti-inflammatory effects. This makes it a versatile peptide with potential applications beyond GH stimulation. It therefore sets it apart from other peptides in the same class.
Does hexarelin give you energy?
It boosts energy indirectly by stimulating growth hormone (GH), which aids metabolism and muscle recovery. While it doesn’t give an instant boost like caffeine, its impact on muscle repair, strength, and overall wellness can enhance vitality over time. Results may vary based on individual factors and research settings.
Does hexarelin increase prolactin?
Yes, it has been shown to increase prolactin levels in some studies. It stimulates the pituitary gland, causing the release of hormones like prolactin. The extent of this increase depends on dosage and individual response. Elevated prolactin may have side effects, and further research is needed to fully understand its implications.
Is hexarelin the same as GHRP-6?
Hexarelin and GHRP-6 are both growth hormone-releasing peptides (GHRPs), but they are not the same. While both stimulate growth hormone (GH) secretion via the pituitary gland, hexarelin is more potent and has longer-lasting effects.
Their chemical structures and receptor binding profiles also differ, leading to variations in effects and potential side effects. Understanding these differences is important for research or therapeutic use.
Buy Hexarelin Peptide Vial from Direct Peptides. Available as lyophilized powder in 2mg and 5mg vials. A kit with syringes and bacteriostatic water for reconstitution is also available for convenience.
Summary of Research Applications
- Pulsatile release of growth hormone.
- Helps reduce fat mass
- Cardioprotective properties
- Tissue repair
- Enhances immune function
- Helps increase metabolism
- Promotes healthy sleep Patterns
- Prevents bone loss
- Promotes lean body mass
Buy Hexarelin Pre-Mixed Peptide 2mg Pen from Direct Peptides. Pre-mixed peptide cartridges are available with or without a full kit. The kit includes a cartridge, pen, carry case, and needle tips, while single cartridges (1, 2, or 3) come with needle tips only.
Save 10% when purchasing 3 cartridges.
Hexarelin Peptide Quality Assured
Direct Peptides provides high-quality Hexarelin peptides with 99% purity, designed to meet strict research standards. Our products are reliable, safe, and precise, giving researchers the confidence to achieve accurate results.
These peptides support studies on growth hormone regulation, cardiovascular health, and metabolic research, helping advance medical studies and therapeutic developments. Buy Hexarelin peptides from Direct Peptides today.
References For Further Reading
[1] S Loche, P Cambiaso, B Merola, A Colao, A Faedda, et al (1995) The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency – Journal of Clinical Endocrinology & Metabolism, 1995 Sep, Volume 80 (Issue 9), Pages 2692-6.
[2] Jinjiang Pang, Qihua Xu, Xiangbin Xu, Hongchao Yin (2010) Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat – Peptides, Volume 31, Issue 4, April 2010, Pages 630-638.
[3] G Bisi, V Podio, M R Valetto, F Broglio, et al (1999) Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans -Journal of Endocrinological Investigation, 1999 Apr, Volume 22 (Issue 4), Pages 266-72.
[4] Bo Jiang, Mo Wang, Xue Li, Pengwei Ren, et al (2022) Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation – Microvascular Research, 2022 Mar, Volume 140, Page 104280.
[5] Jin-Jiang Pang, Rong-Kun Xu, Xiang-Bin Xu, Ji-Min Cao, et al (2004) Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro – American Journal of Physiology: Heart & Circulation Physiology, 2004 Mar, Volume 286 (Issue 3), Pages H1063-9.
[6] Anna Barlind, Niklas Karlsson, N. David Åberg, et al (2010) The growth hormone secretagogue hexarelin increases cell proliferation in neurogenic regions of the mouse hippocampus – Growth Hormone & IGF Research, Volume 20, Issue 1, February 2010, Pages 49-54.
[7] H. McDonald, J. Peart, N.D. Kurniawan, et al (2020) Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion – Biomedicine & Pharmacotherapy, Volume 127, July 2020, 110165.
[8] Vanessa Zambelli, Laura Rizzi, Paolo Delvecchio, Elena Bresciani, et al (2021) Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury – Drug Target Insights, 2021 Nov 27, Volume 15, Pages 26-33.
[9] V De Gennaro-Colonna, G Rossoni, D Cocchi, A E Rigamonti, F Berti, and E E Muller (2000) Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker rats – Journal of Endocrinology, 2000 Sep, Volume 166 (Issue 3), Pages 529-36.
[10] V Sibilia, D Cocchi, F Pagani, N Lattuada, et al (1999) Hexarelin, a growth hormone – releasing peptide, counteracts bone loss in gonadectomized male rats – Growth Hormone & IGF Research, 1999 Aug, Volume 9 (Issue 4), Pages 219-27.
[11] Elena Conte, Giulia Maria Camerino, Antonietta Mele, Michela De Bellis, et al (2017) Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia – Journal of Cachexia, Sarcopenia and Muscle, 2017 Jun, Volume 8 (Issue 3), Pages 386-404.
[12] Giuseppe Sirago, Elena Conte, Flavio Fracasso, Antonella Cormio, et al (2017) Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia – Scientific Reports, 2017 Oct 12, Volume 7, Page 13017.
[13] Ralf-Michael Frieboes, Irina A. Antonijevic, Katja Held, Harald Murck,et al (2004) Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers – Psychoneuroendocrinology, Volume 29, Issue 7, August 2004, Pages 851-860.
Why Choose Direct Peptides ?
Buy Hexarelin today from Direct Peptides, your trusted source for high-quality Hexarelin peptides. We offer a wide range of formulations to meet your needs, including peptide vials in 2 mg and 5 mg, peptide stacks designed for potential synergistic effects, nasal sprays in 15 ml and 30 ml bottles, and 2 mg pre-mixed peptide pens. Whatever your research requirements, we provide the precise formulations you need to support your projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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