Buy Gonadorelin Peptide
Buy Gonadorelin peptide, a synthetic hormone that stimulates the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). It offers potential benefits in hormone replacement therapy, early detection of hormone-related conditions, and research into reproductive and cognitive health.
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Gonadorelin Nasal Spray
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Gonadorelin
£12.38 – £21.36 This product has multiple variants. The options may be chosen on the product page
What Is Gonadorelin?
Gonadorelin is a synthetic decapeptide that mimics the action of the natural gonadotropin-releasing hormone (GnRH) produced by the hypothalamus in the human body. Its primary function is to regulate the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland.
These hormones play pivotal roles in reproductive processes, including ovulation in females and spermatogenesis (sperm production) in males. It is widely used in research and medical applications. It serves as both a diagnostic agent and a therapeutic tool.
For example, it can help assess pituitary and hypothalamic function or treat hormonal disorders such as amenorrhea (absence of menstrual periods) or delayed puberty. Additionally, it has applications in studying hormone-driven conditions like prostate and breast cancer, as it provides insights into how hormone regulation impacts cancer cell growth.
The peptide is also utilised in laboratory studies to research its potential effects on cognitive function, Alzheimer’s disease, and hormone-related changes during menopause. The peptide’s structure, composed of ten amino acids, allows researchers to better understand hormone synthesis and interactions, making it a valuable tool in advancing endocrinology and related fields.
Gonadorelin Mechanism Of Action
Synthetic peptide Gonadorelin works by stimulating the release of two important hormones, LH and FSH, from the anterior pituitary gland. It binds to specific receptors for gonadotropin-releasing hormone (GnRH) on pituitary cells. This triggers a signaling process through G-proteins and the phospholipase C pathway. The process increases calcium levels inside the cells, causing the secretion of LH and FSH into the bloodstream. These hormones are crucial for reproductive functions, such as ovulation in females and sperm production in males.
The way it is administered matters: when given in pulses, it mimics the body’s natural GnRH secretion, ensuring proper hormone release and maintaining balance. However, continuous administration has the opposite effect, causing the receptors to become less sensitive and reducing gonadotropin secretion. This effect is useful in treating conditions like hormone-sensitive cancers or early puberty. The compound’s ability to regulate these processes makes it a valuable tool in both clinical and research settings.
Structure of Gonadorelin
Sequence: H-Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Molecular Formula: C55H75N17O13
Molecular Weight: 1182.3 g/mol
PubChem CID: 638793
What Are The Research Benefits of Gonadorelin
Restoration of Fertility
Studies have shown that the peptide is instrumental in treating conditions like hypothalamic amenorrhea [1] or hypogonadotropic hypogonadism [2]. By stimulating the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), it helps restore normal reproductive function. This makes it particularly valuable in assisted reproductive technologies such as in vitro fertilisation (IVF), where optimising hormonal balance and supporting ovulation are critical for success [3].
Additionally, it plays a critical role in addressing hormonal imbalances caused by exogenous testosterone or anabolic steroid use. By promoting the natural production of LH and FSH, gonadorelin helps to mitigate the suppression of endogenous testosterone production, supporting hormonal recovery and overall health [4] [5].
Support for Diagnostic Procedures
It is utilised in diagnostic tests to evaluate the functionality of the hypothalamic-pituitary-gonadal axis. This helps clinicians identify underlying causes of hormonal disorders and infertility issues effectively [6].
Advancements in Endocrine Therapy
Continuous infusion of gonadorelin aids in conditions requiring hormonal suppression, such as managing hormone-sensitive cancers or endometriosis, by achieving down-regulation of gonadotropins.
Breast Cancer Prevention
Gonadorelin administration and its GnRH analogues have been explored in the management of hormone-sensitive breast cancer. By modulating the secretion of gonadotropins, these therapies can suppress ovarian function, reducing estrogen and progesterone levels, which may otherwise stimulate the growth of hormone receptor-positive breast cancer cells [7]. This approach forms part of endocrine therapy strategies to complement other treatment modalities, such as chemotherapy or surgery, providing a comprehensive plan for managing breast cancer.
Prostate Cancer Treatment
Similarly, gonadotropin-releasing hormone analogues have been utilised in prostate cancer treatment [8]. By suppressing the production of testosterone in the testes, which can fuel the growth of prostate cancer cells, these therapies play a crucial role in androgen deprivation therapy (ADT) [9]. This form of treatment is often combined with other approaches such as radiotherapy or surgery to optimise outcomes. The ability to effectively lower androgen levels by targeting the testes makes this strategy a cornerstone in the management of hormone-sensitive prostate cancer.
Precise Control of Hormonal Release
Through tailored dosing regimens, the peptide allows for precise control of LH and FSH release, enabling targeted therapeutic applications to support various hormonal deficiencies or imbalances.
Potential in Alzheimer’s and Cognitive Disorders
Recent animal studies suggest that gonadorelin may hold promise in the field of neurology, particularly in addressing Alzheimer’s disease and other cognitive disorders [10]. Its role in regulating hormonal pathways is thought to have implications for cognitive function. This is due to disruptions in these pathways which have been linked to neurodegenerative conditions. Further research is underway to explore its potential therapeutic applications, offering hope for innovative treatment options in this critical area.
One significant factor in the research surrounding cognitive disorders like Alzheimer’s disease is the apolipoprotein E (APOE) gene [11]. Variations in the APOE gene, particularly the APOE ε4 allele, have been strongly associated with an increased risk of developing Alzheimer’s. This genetic marker plays a key role in lipid metabolism and influences the accumulation of amyloid plaques in the brain—a hallmark of Alzheimer’s disease. Understanding the interaction between APOE variants and hormonal pathways regulated by gonadorelin could provide deeper insights into disease mechanisms and open new avenues for targeted therapeutic interventions.
Buy Gonadorelin Peptide Vial for laboratory purposes from Direct Peptides. Available as a 2mg vial or as a kit which includes syringes and bacteriostatic water for reconstituting the lyophilised powder.
Buy Gonadorelin Pre-Mixed Pen
Buy Gonadorelin pre-mixed peptide 2 mg pen . It offers a hassle-free solution for precise and efficient peptide administration. It includes pre-mixed cartridges (peptide pre-mixed with bacteriostatic water), a user-friendly pen, and essential accessories like needle tips and a carry case.
Single cartridges are available in options of 1, 2, or 3, with a 10% discount for purchasing three. This system simplifies preparation, ensures accuracy, and delivers consistent results.
Buy Gonadorelin Peptide Nasal Spray
Buy Gonadorelin Peptide Nasal Spray for a convenient alternative to injections. Available in two strengths, the 15 ml bottle contains 2 mg of Gonadorelin, while the 30 ml bottle contains 4 mg for a longer-lasting option.
The nasal spray is easy to use and delivers precise doses directly into the bloodstream through the nasal mucosa, eliminating the need for needles.
Frequently Asked Questions (FAQs) about Gonadorelin
What are the side effects of Gonadorelin?
Gonadorelin, used primarily for research, may cause mild side effects like irritation at the injection site, headache, nausea, flushing, dizziness, or menopause-like symptoms such as hot flashes and mood changes. These effects are typically temporary. Responsible research practices and careful monitoring are essential to ensure safety. Always follow professional protocols and regulations when.
Is Gonadorelin legal?
Yes, it is legal when used for research purposes within the appropriate regulatory framework. It is important to note that it has not been approved by the United States Food and Drug Administration (FDA) for general use in humans or animals outside specific controlled research environments. Researchers must ensure compliance with local regulations and guidelines when using it in experimental settings.
Can Gonadorelin Replace HCG?
Gonadorelin and HCG (human chorionic gonadotropin) serve different functions but are sometimes compared in therapy. Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) that stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). HCG, on the other hand, directly mimics LH and is often used to trigger ovulation or boost testosterone.
While Gonadorelin affects LH and FSH production indirectly, it may not provide the same immediate or targeted effects as HCG. Whether Gonadorelin can replace HCG depends on clinical goals and patient needs. More research is needed to clarify its effectiveness in comparison to HCG.
Always consult a medical professional to determine the best option for your studies.
How is Gonadorelin administered?
Administration of Gonadorelin can be via injections or as a nasal spray. Nasal sprays are especially favoured for their ease of use, precise dosing, and needle-free application.
Buy Gonadorelin for research online today!
Summary of Research Applications
- Stimulates LH and FSH hormones to improve fertility
- Regulates ovulation in women
- Promotes sperm production in men
- May help treat hypogonadism
- Mimics the menopause to relieve symptoms of Endometriosis, Menorrhagia and PCOS
- Potential to treat patients with delayed puberty
- Diagnostic tool for breast cancers and prostate cancers
- A key peptide for advancing research into Alzheimer’s and other cognitive disorders.
Gonadorelin Peptide Quality Assured
At Direct Peptides, we provide 99% pure Gonadorelin peptides made to strict quality standards for research. Choosing our peptides means researchers get safe, reliable, and precise products.
These peptides support studies on fertility, reproductive health, and endocrine disorders, helping advance medical research and patient care. Buy Gonadorelin peptides from Direct Peptides today.
References For Further Reading
[1] Nanette Santoro (1990) Efficacy and safety of intravenous pulsatile gonadotropin-releasing hormone: Lutrepulse for injection – American Journal of Obstetrics and Gynecology, Volume 163, Issue 5, Part 2, November 1990, Pages 1759-1764.
[2] J Rajkanna, S Tariq, and S O Oyibo (2016) Successful fertility treatment with gonadotrophin therapy for male hypogonadotrophic hypogonadism – Endocrinology, Diabetes & Metabolism Case Reports, 2016 Jan 7, Edition 2016, Page 150124.
[3] Ektoras X Georgiou, Pedro Melo, Philip E Baker, Hassan N Sallam, et al (2019) Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis – Cochrane Database of Systematic Reviews, 2019 Jan 8, Version 2019 (1),CD013240.
[4] Jurandir Joaquim Bernardes Júnior, Robie Allan Bombardelli, and Alex Pires de Oliveira Nuñer (2017) Gonadorelin increases semen production and does not affect its quality in Leporinus obtusidens – Animal Reproduction Science, 2017 Oct, Volume 185, Pages 154-160.
[5] D J Kesler, R N Summers, C A Peterson, and T L Steckler (1999) Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine – Drug Development and Industrial Pharmacy, 1999 Mar, Volume 25 (Issue 3), Pages 315-21.
[6] Kanyada Koysombat, Waljit S Dhillo, and Ali Abbara (2023) Assessing hypothalamic pituitary gonadal function in reproductive disorders – Clinical Science (London), 2023 Jun 14, Volume 137 (Issue 11), Pages 863-879.
[7] Maira Huerta-Reyes, Guadalupe Maya-Núñez, Marco Allán Pérez-Solis, et al (2019) Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs – Frontiers in Oncology, 2019 Oct 1, Volume 9, Page 943.
[8] Fernand Labrie (2010) Hormonal therapy of prostate cancer – Progress in Brain Research, 2010, Volume 182, Pages 321-41.
[9] Seungtaek Choi and Andrew K Lee (2011) Efficacy and safety of gonadotropin-releasing hormone agonists used in the treatment of prostate cancer – Drug, Healthcare and Patient Safety, 2011 Dec 22, Volume 3, Pages 107–119.
[10] C V Rao (2017) Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women – Reproductive Science, 2017 Mar, Volume 24 (Issue 3), Pages 355-368
[11] Alejandro Cáceres, José E Vargas, and Juan R González (2017) APOE and MS4A6A interact with GnRH signaling in Alzheimer’s disease: Enrichment of epistatic effects – Alzheimers & Dementia, 2017 Apr, Volume 13 (Issue 4), Pages 493-497.
Why Choose Direct Peptides ?
Buy Gonadorelin for research use today from Direct Peptides, your trusted source for high-quality peptides. We offer a range of GnRH formulations, including 2mg peptide vials, 15ml and 30ml nasal sprays, and pre-mixed peptide pens. Designed to meet diverse research needs, we ensure researchers have the exact formulation for their projects.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
